摘要
综合国内外相关文献报道,对生物技术药物口服微粒给药系统在胃肠道中的吸收机制、所遇到的主要障碍、影响因素、提高生物利用度的策略以及常用生物技术药物口服微粒给药系统等进行综述,旨在为新型生物技术药物口服给药系统提供思路和方法。
This article reviewed progressions of oral microparticle delivery systems of biopharmaceutics by focusing on the absorption of drug substance through the gastrointestinal tract, the effects of physical barriers and other factors on the absorption, and the optima of bioavailability of the system. The practice conditions of the delivery system are briefly discussed to provide the rationale and knowledge that the advanced researchers need.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2005年第1期18-23,共6页
Chinese Journal of New Drugs
关键词
生物技术药物
口服微粒给药系统
生物利用度
biopharmaceutical drugs
oral microparticle delivery system
bioavailability
