摘要
目的:合成骨化三醇。方法:以维生素D_2为原料,先用二氧化硫(SO_2)使其异构化,再以SO_2保护共轭双键,臭氧氧化,接入支链,光照使其异构化为顺式产物,然后脱去保护基,即得目标产物。结果:合成了骨化三醇,总收率为17.1%。结论:新方法免去了氰化钠的使用,收率提高,操作安全,适合于工业化生产。
Objective : To synthesize calcitriol. Methods: Using vitamin D_2 as a starting material, the target compound was synthesized via an 8-step chain reaction. The cis isomer of the calcitriol was confirmed using TLC and spectroscopies. Results:The overall yield rate of calcitriol was 17.1%. Conclusion:The synthetic process that waived the NaCN involvement in the reaction becomes more attractive for the manufacture on a large scale.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2005年第1期69-72,共4页
Chinese Journal of New Drugs
