摘要
目的:分析激素性股骨头缺血坏死(ANFH)模型不同时期的股骨头MR灌注情况,并与病理学结果相对照。方法:20只健康日本大耳白兔,分别于给药前和给药后2周、4周、6周、8周以相同方法行MR常规及Gd-DTPA灌注增强扫描,绘出股骨头的时间-信号强度变化动态曲线,分析股骨头不同阶段骨髓信号强度变化的情况。处死后取材采用HE染色光镜观察及电镜超微结构分析。结果:早期激素性ANFH血流灌注初期时间-信号强度变化曲线的斜率逐渐减小,且灌注的强度逐渐下降(P<0.01)。相应的骨小梁空虚骨陷窝数逐渐增多(P<0.01)。结论:股骨头部各种细胞的脂肪变性与坏死是激素性ANFH的早期病理改变,应用快速MR动态增强技术能够检查股骨头的血流灌注情况,二者有显著相关。
Objective To analyze marrow perfusion of the model of steroid induced ANFH and invesigate the corresponding pathological changes in the femoral head of different stage of ischemia. Materials and Methods Twenty Japanese white rabbits were examined by MR in the same method before treatment and in the second week fourth week sixth week and eighth week after treatment. Time signal intensity dynamic curve was depicted to analyze the marrow signal intensity changes of femoral head in different stage of ischemia. After rabbits were killed sample were examined histologically. HE stained specimen and EM ultramicrostructure were analyzed. Results The slope of time signal intensity curve gradually declined in early stage of blood perfusion and intensity of perfusion decreased gradually(P<0.01). Correspondlingly the number of empty lacuna increased gradually(P<0.01). Conclusion The main pathological changes of steroid induced ANFH in the early stage were fat degeneration and necrosis of various kinds of cells in femoral head. Dynamic enhanced technique can evaluate the state of blood perfusion of femoral head.
出处
《中国临床医学影像杂志》
CAS
北大核心
2005年第2期92-96,共5页
Journal of China Clinic Medical Imaging
基金
辽宁省科学技术计划资助项目(编号00225001-13)
关键词
股骨头坏死
磁共振成像
femur head necrosis magnetic resonance imaging
