摘要
目的:文章结合学习记忆的神经机制回顾了铝对学习记忆损害及可能途径,以阐明铝对学习记忆的毒性机制,进而寻求有效的预防和治疗方法,减少铝中毒的发病率。资料来源:应用计算机检索Medline数据库1980-01/2004-06期间的相关文章,检索词为“aluminum和“memory,LTP,PKC,Ca2+,GABA,acetylcholine,分别组合进行检索,限定文章语言种类为英文。同时计算机检索中国期刊全文数据库、万方数据库1990-01/2004-06期间的相关文章,检索词“铝,学习记忆,长时程增强,钙,蛋白激酶C,GABA,乙酰胆碱,限定文章语言种类为中文。资料选择:对资料进行初审,选取试验包括上述干预组和对照组的文献,然后筛除非随机试验的研究,对剩余的文献开始查找全文。资料提炼:共收集到13篇关于铝对学习记忆影响及对长时程增强影响的试验,9个试验符合纳入标准,排除4篇。另收集到5篇铝对Ca2+影响的试验、3篇铝对蛋白激酶C影响的试验、12篇对神经递质影响的试验,其中11个试验符合纳入标准,排除9篇。资料综合:9个试验干预措施均选用了慢性给铝(或长期接触铝)和急性给铝两种方法,观测指标主要包括动物的学习记忆行为的改变及观测突触传递的长时程增强现象的改变。铝对学习记忆和突触传递长时程增强的影响进行了对照研究及相关性分析。
OBJECTIVE:The study reviewed the lesion of aluminium in learning memory and its possible pathway combined with nerval mechanism of learning memory to illuminate its toxicity mechanism in learning memory in order to search effective methods to prevent and treat aluminium toxicosis and reduce the incidence rate. DATA SOURCES:Using the key terms “aluminum memory,LTP,PKC,Ca2+,GABA,acetylcholine”,we searched the MEDLINE database of all relevant articles in English between January 1980 and June 2004.Meanwhile,using the same key terms in Chinese we searched the Chinese journals full text database,Wanfang database between January 1990 and June 2004. STUDY SELECTION:All articles were selected firstly and the articles containing the mentioned treatment group and control group were selected.The full text of rest literatures except investigations of non randomized trial was looked up. The randomized controlled clinical trials(RCT) were accepted as inclusive criteria. DATA EXTRACTION:Totally 13 articles of randomized and non rando mized trials were collected,which were relevant to the effect of aluminium on learning memory and long term potentiation(LTP).Among them,9 articles met inclusion criteria,and 4 articles were excluded.Another 5,3,12 articles of randomized and non randomized trial about the effect of aluminium on Ca2+,PKC and neurotransmitter were collected.Among them,11 articles met inclusion criteria, and 9 articles were excluded. DATA SYNTHESIS:Totally 9 intervention studies received the methods of chronic given and acute given aluminium.The changes of learning memory and LTP of synaptic transmission were contained as main indexes of observation.The effects of aluminium on learning memory and LTP were investigated and anylized. CONCLUSION:The aluminium can destroy the function of learning memory.The learning memories of persons or animals contacted with aluminium for a long time or with chronic given aluminium decrease to different degree.LTP of animals with acute given aluminium are inhibited obvioualy.The lesion of aluminium on learning memory relates to the change of intracellular calci homeostasis,the decrease of PKC activity and some neurotransmitters which can change the learning memory,such as,aminoglutaric acid,gamma aminobutyric acid, acetylcholine,etc.
出处
《中国临床康复》
CSCD
北大核心
2005年第5期140-142,共3页
Chinese Journal of Clinical Rehabilitation
