摘要
以放射配体法测定外周血白细胞糖皮质激素受体(GR),并用放免双抗体法测定血浆皮质醇(F)浓度。在慢性特发性血小板减少性紫癜(CITP)组30例中,GR数量为3893±275位点/细胞((?)±S(?));而正常对照组22名为5306±249位点/细胞(P<0.01)。两组F均正常,且无明显差异。16例病人用强的松正规治疗并观察近期反应,有效12例,无效4例,GR分别为4975±351和2760±316位点/细胞(P<0.01)。由此表明,CITP病人组白细胞GR平均数量较正常对照组明显降低;病人白细胞GR水平与糖皮质激素近期疗效密切相关。
In the study, we measured glucocorticoid receptor (GR) in the peripheral leucocytes by radio-ligand assay and plasma cortisol (F) by radio-immune method. The mean CR level of 30 pati- ents with chronic ITP was 3983±275 sites/cell ((?)+s) and that of the 22 in the normal controls 5306±249 sites/cell (P<0.01). F concentration of both groups was within normal range and there was no significant difference between them (P>0.05). 16 patients were given a prednisone (PDN) therapy, and the responce within 8 weeks was observed. GR of 12 cases responsive to PDN were 4975±351 sites/cell, but 4 cases with no responce to PDN were 2760±316 sites/cell (P<0.01). These results suggested, comparing, to normal control group, the mean GR level in patients of chronic ITP group reduced obviously, and there is a close relationship between the GR level the short-term therapeutic effect of glucocorticoid in the patients.
出处
《铁道医学》
1993年第1期17-19,共3页
Railway Medical Journal
关键词
紫癜
血小板减少
受体
receptors, endegenous, prednisone, purpura, thrombopenie
