期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

环氧化酶在肿瘤监测中的应用 被引量：2

下载PDF
导出
摘要 环氧化酶(cyclooxygenase,COX)又称前列腺素内氧化酶还原酶,是一种双功能酶,具有环氧化酶和过氧化氢酶活性,是催化花生四烯酸转化为前列腺素的关键酶.研究发现,COX至少有COX-1(结构型)和COX-2(诱导型)两种同工酶.前者在多数组织细胞内呈稳定表达,主要参与机体各种生理功能的调节;后者在正常组织细胞中多不表达,生长因子、细胞因子和肿瘤促进剂可刺激其表达,参与多种生理、病理过程.大量资料表明,COX-2参与肿瘤形成,可能是通过促进细胞增殖和抑制细胞凋亡而实现的.
作者 侯振江
机构地区 河北省沧州医学高等专科学校
出处 《检验医学与临床》 CAS 2004年第2期76-78,共3页 Laboratory Medicine and Clinic
关键词 环氧化酶 肿瘤监测 COX 双功能酶 免疫组化法
分类号 R730.4 [医药卫生—肿瘤]
  • 相关文献

参考文献12

  • 1[1]Liu CH,Chang SH,Joarder FS,et al.Overexpression of cyclooxgenase-2 is sufficient to induce tumorin genesis in transgenic mice.J Biol Chem,2001,267(23):18563-18569.
  • 2[3]Ristimaki A,Sivula A,Lundin J,et al.Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer.Cancer Res,2002,62 (3):32-635.
  • 3[4]Hasturk S,Kemp B,Kalapurakai SK,et al.Expression of clooxygenase-1 and cyclooxygenase-2 in bronchial epithelium and non-small cell lung carcinoma.Cancer,2002,94 (4):1023-1031.
  • 4田锋,王天佑,龚民,卢晓梅,胡健,王京,张长淮.非小细胞肺癌环氧化酶-2的增强表达及其临床意义[J].中华外科杂志,2003,41(6):407-410. 被引量：12
  • 5[6]Fadlo RK,Hong WJ,Jack L,et al.Cyclooxygenase-2 overexpression is a marker of poor prognosis in stage 1 nonsmall cell lung cancer.Clin Canrcer Res,2001,7 (2):861-867.
  • 6[7]Buskens CJ,Van Rees BP,Sivula A,et al.Prognostic significance of elevated cyclooxygenase 2 expression in patients with adenocarcionma of the esophagus.Gastroerology,2002,122(7):1800-1807.
  • 7陈荣华,李建生,师晓天.COX-2和MMP-2的表达与食管癌侵袭转移的关系[J].胃肠病学和肝病学杂志,2003,12(2):169-171. 被引量：14
  • 8[10]Merati K,Said SM,Andea A,et al.Expression of inflammatory modulator COX-2 in to pancreatic ductal adenocarcioma and its relationship to panthologic and clinical parameters.Am J Clin Oncol,2001,24(3):447-452.
  • 9[11]Zhang H,Sun XF.Overexpression of cyclooxygenase-2 correlates with advanced stages of colorectal cancer.Am J Gastroenterol,2002,97 (4):1037-1041.
  • 10李志坚,张学斌,高新,万云霞,马建辉,陈毓仙.环氧化酶-2在肾癌组织中的表达——附65例临床分析[J].新医学,2003,34(10):616-617. 被引量：5

二级参考文献26

  • 1Ji F,Wang WL,Yang ZL,Li YM,Huang HD,Chen WD.Study on the expression of matrix metalloproteinase-2 mRNA in human gastric cancer[J].World Journal of Gastroenterology,1999,5(5):455-457. 被引量：19
  • 2Khan KN, Stanfield KM, Tmjkovic D. Expression of cyclooxygenase-2 in canine renal cell carcinoma. Vet Pathol, 20OI, 38 ( 1 ) : 116-119.
  • 3Khan KN, Stanfield KM, Dannenberg A, et al. Cyclooxygenase-2 expression in the developing human kidney. Pediatr Dev Pathol, 2001, 4 (5):461-466.
  • 4Hida T, Kozaki KI, Muramatsu H, et al. Cyclooxygenase-2 inbibitor induces apoptosis and e~mces cytoxicity of various snticanear agents in non-small cell lung cancer cell lines. Clin Cancer Res, 2000, 60 (6):2006-2011.
  • 5Kishi K. Petersen S, Petersen C, et al. Preferential enhencemeatof tumor radioresponse by a cyclooxygenase-2 inhibitor. Cancer Res, 2000, 60 (3):1326-1331.
  • 6Dubois RN, Abramson SB, Crofford L, et al. Cyclooxygenase in biology and disease. FASEB J, 1998, 12 (4): 1063-1073.
  • 7Tsujii M, Kawano S, Tsuji S, et al. Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell, 1998, 93:705-716.
  • 8Yukio H,Tomoyuki Y,Yuko H,et al.Increased cyclooxygenase 2(COX-2) expression occurs frequently in precursor lesions of humam adenocarcinoma of the lung. Lung Cancer, 2000,30:73-81.
  • 9Henrik W, Kirsi S, Sisko A, et al. Expression of cyclooxygenase 2 in humam lung carcinoma.Cancer Res,1998,58:4997-5001.
  • 10Fadlo RK, Hong WJ, Jack L, et al. Cyclooxygenase 2 overexpression is a marker of poor prognosis in stage Ⅰ non-small cell lung cancer.Clin Cancer Res,2001,7:861-867.

共引文献28

同被引文献13

  • 1刘敏,纪新强,曲迅.上皮性卵巢肿瘤组织中端粒酶活性的表达及与临床病理因素相关性研究[J].肿瘤防治杂志,2005,12(1):25-28. 被引量：1
  • 2Murakami J, Nagai N, Ohama K, et al. Telomerase activity in ovarian tumor[ J]. Cancer, 1997,80 : 1085.
  • 3Kyo S, Kanaya T, Ishikawa H. Telomerase activity in gynecological tumors[J]. Clin Cancer Res, 1996,2:2023.
  • 4Kyo S, Takakura M, Tanaka M, et al. Quantitative differences in telomerase activity among malignant, premalignant, and benign ovarian lesions[J]. Clin Cancer Res,1998,4(2) :399-405.
  • 5Kyo S, Kanays T, Takakura M, et al. Expression of telomerase subuits in ovarian malignant, borderline and benign tumors [ J ]. Int J Cancer, 1999,80(6) :804-809.
  • 6Di-Nezza LA, Misajon A, Zhang J, et al. Presence of active gelatinases in endometrial carcinoma and correlation of matrix metalloproteinase expression with increasing tumor grade and invasion [ J ]. Cancer,2002,94 (5) : 1466-1475.
  • 7Davidson B, Goldberg I, Berner A, et al. EMMPRIN ( extracellular matrix metalloproteinase inducer ) is a novel marker of poor outcome in serous ovarian carcinima [ J ]. Clin Eep Metastasis, 2003,20 ( 2 ) : 161-169.
  • 8Denkert C, Kobel M, Pest S, et al. Expression of cyclooxygenase - 2 is an independent prognostic factor in human ovarian carcinoma [ J]. Am J Pathol,2002,160(3 ) :893-901.
  • 9Green JA, Robertson LJ, Clzrk AH, et al. Glutathione S-transferase expression in benign and malignant ovarian tumors [ J ]. Br J Cancer, 1993,68:235-239.
  • 10王宏,李春海,陈高明,孙丽亚,卞丽红,杨毅,毛慧生.GST-π类同工酶基因在卵巢癌组织中的表达及其与癌变的关系[J].中国肿瘤临床,1999,26(11):836-838. 被引量：1

引证文献2

二级引证文献1

检验医学与临床
2004年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部