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自身免疫溶血性贫血患者抗体筛选观察 被引量:15

Observation of Antibody Screen of Patients with Autoimmune Hemolytic Anemia
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摘要 为了观察自身免疫溶血性贫血 (AIHA)患者的同种抗体 ,用氯奎放散试验检测自身抗体掩盖的同种抗体 ,用乙醚放散试验检测自身抗体的特异性。结果表明 :3 8例AIHA病人中 ,间抗阳性者 19例 ,其中含同种抗体者 7例 (抗 D 1例 ,抗 E 4例 ,抗 CE 2例 ) ,自身抗体具有血型特异性者 5例 (抗 E 3例 ,抗 C 1例 ,抗 c 1例 )。结论 :采用氯奎放散试验、乙醚放散试验等检测被自身抗体掩盖的同种抗体 ,对AIHA患者的安全输血很重要。 To observe of alloantibodies of patients with autoimmune hemolytic anemia (AIHA), the alloantibodies masked by autoiantibody were detected by using chloroquine elution test, and the specificity of autoantibody was identified by ether elution test. The results showed that 19 cases out of 38 patients with AIHA were positive detected by indirect antiglobulin test and in 7 cases of them alloantibodies in sera cases were found (1 case of anti D, 4 cases of anti E and 2 cases of anti CE), in 5 cases of them alloantibody were detected carried blood group specificity (3 cases of anti E, anti C and anti c 1case repectively). In conclusion, detections of alloantibodies by chloroquine elution test and ether elution test were very important for transfusion safety in therapy of patients with AIHA.
出处 《中国实验血液学杂志》 CAS CSCD 2004年第6期849-851,共3页 Journal of Experimental Hematology
关键词 自身免疫性溶血性贫血 抗体筛选 同种抗体 autoimmune hemolytic anemia antibody screen alloantibody
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参考文献3

  • 1LanJC, Chen Q, Wu DL, et al. Genetic polymorphism of RhD-negative associated haplotypes in the Chinese. J Hum Genet, 2000;45: 224 - 227
  • 2兰炯采 胡利亚 杨世英.氯奎放散法研究[J].中华血液学杂志,1988,9:624-625.
  • 3朱剑荧,兰炯采,胡利亚,孟庆宝,罗洪清.自身免疫性溶血性贫血患者的血型检定研究[J].中国实验血液学杂志,2004,12(4):525-527. 被引量:5

二级参考文献4

  • 1Lan JC, Chen Q, Wu DL, et al. Genetic polymorphism of RhDnegative associated haplotypes in the Chinese. J Hum Genet, 2000;45: 224 - 227
  • 2邓家栋 杨崇礼 杨天楹.临床输血学[M].上海:上海科学技术出版社,2001.637-638.
  • 3兰炯采 胡利亚 杨世英.氯奎放散的研究[J].中华血液学杂志,1989,9:624-625.
  • 4兰炯采,孟庆宝,张印则,周华发,王从容,曹琼,刘忠.ABO血型基因分型及应用[J].中国免疫学杂志,2002,18(6):430-433. 被引量:29

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