摘要
目的 评价18氟 脱氧葡萄糖 (18F FDG)三探头符合线路SPECT显像在诊断肿瘤性质的临床应用价值。方法 对 4 4例临床怀疑为恶性肿瘤或肿瘤转移复发的患者 ,空腹静脉注射18F FDG 370～ 5 5 5MBq后 4 5～ 6 0min ,采用PhilipsIRIX三探头符合线路SPECT进行显像 ,经迭代重建 ,获得横断面、冠状面和矢状面三维断层图像 ,以目测双盲阅片和计算病灶感兴趣区 (ROI)与同一平面对侧正常组织 (L/B)的放射性比值进行诊断分析 ,并与手术、组织病理或影像学和临床随访作出的最后诊断进行比较。结果 4 4例患者中最后确诊为恶性者 34例 ,良性者 10例。恶性组L/B值为 5 .76± 3.38,良性组L/B值为 2 .0 1± 0 .74。两组患者的L/B比值差异显著 (P =0 .0 0 0 )。采用受检者工作特征 (ROC)曲线分析 ,以L/B值 2 .0为区分良恶性病变的分界值时 ,18F FDG三探头符合线路SPECT显像对肿瘤或其转移复发灶诊断的灵敏度为 94 .1% (32 /34)、特异性为 80 % (8/10 )、准确性为 90 .1% (40 /44)。结论 18F FDG三探头符合线路SPECT显像对肿瘤的诊断具有较高的灵敏度和特异性 ,在鉴别肿瘤良恶性、寻找肿瘤转移复发灶方面有较高的临床实用价值。
Objective To evaluate the clinical value of 18F-FDG three-head coincidence SPECT imaging in oncologic diagnosis. Methods 44 patients with suspected malignant or recurrent tumors underwent 18F-FDG coincidence imaging using Philips IRIX three-head coincidence SPECT. After reconstruction using iterative algorithm, the transaxial, coronal and sagittal sections were obtained. The images were interpreted visually, and also the values of lesion/background (L/B) were calculated. The final diagnoses of these patients were proved either by histopathology or by biopsy, or by a clinical and radiographic follow-up. Results Thirty-four patients were proven to have malignant,, and 10 patients had benign disease. The L/B value of the malignant group was 5.76±3.38, and the value of the benign group was 2.01±0.74, significantly different from each other (P=0.000). When applying a L/B value threshold of 2.0 for separating benign from malignant lesions based on the receiver operation characteristic curve (ROC), the sensitivity, specificity and accuracy of 18F-FDG three-head coincidence SPECT imaging were 94.1% (32/34) , 80% (8/10) , 90.1% (40/44) , respectively.Conclusion 18F-FDG three-head coincidence SPECT imaging had high sensitivity and specificity in tumor diagnosis, and had practical values in differentiating malignant from benign processes and in detecting recurrence or metastases.
出处
《中国血液流变学杂志》
CAS
2004年第4期573-576,共4页
Chinese Journal of Hemorheology
