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普伐他汀和福辛普利对糖尿病大鼠肾小球中TGF-β_1的影响 被引量:1

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摘要 目的 研究普伐他汀与福辛普利联合使用对糖尿病大鼠肾小球中TGF -β1的影响 ,探讨其对糖尿病肾病的保护机制。方法 将 40只SD大鼠随机分为对照组、糖尿病组、普伐他汀组、普伐他汀联合福辛普利组 (联合组 ) ,每组 10只。给予普伐他汀 (2 0mg·Kg-1·d-1)和福辛普利 (15mg·Kg-1·d-1)治疗 12周后 ,观察大鼠UPE、LDL、Scr及左肾重 /体重 ,免疫组化LSAB法检测肾小球中TGF -β1和FN的表达 ,并采用医学病理图像分析系统测定肾小球系膜基质指数 (M/G)。结果 联合组与普伐他汀组比较 ,各生化指标无显著性差异 ,但UPE、左肾重 /体重比值、M/G明显减少 (P <0 0 5 ) ;肾小球中TGF -β1的表达下调 (P <0 0 5 ) ,同时FN表达亦相应下调(P <0 0 5 )。结论 普伐他汀和福辛普利联合较单独应用普伐他汀使糖尿病大鼠肾小球中TGF -β1的表达下调更明显 。
出处 《中国医师杂志》 CAS 2004年第12期1655-1657,共3页 Journal of Chinese Physician
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