摘要
目的:探讨大肠癌组织中基质金属蛋白酶-9(MMP-9)及其基质金属蛋白酶抑制剂-2(TIMP-2)的表达与临床病理指标之间的关系。方法:收集桂林医学院附属医院1996-10/2002-10手术切除或肠镜活检的大肠癌标本108个。采用S-P免疫组织化学染色技术,检测108个大肠癌组织中MMP-9和TIMP-2蛋白的表达情况。结果:108个大肠癌组织中MMP-9和TIMP-2表达的阳性率分别为60.2%(65/108)和25.0%(27/108);MMP-9的表达在肿瘤浸润度深、有淋巴结转移、Dukes分期晚及生存期短的患者中表达率高(P<0.0001),而TIMP-2的表达则相反;MMP-9和TIMP-2的表达与性别、年龄、肿瘤部位、病理类型和分化程度均无关(P>0.05)。结论:MMP-9和TIMP-2可作为判断大肠癌恶性程度、转移及预后的重要参考指标。
AIM:To study the expressions of matrix metalloproteinase 9(MMP 9) and tissue inhibitor of metalloproteinase 2(TIMP 2) in colorectal carcinoma and their relationships with clinicopathological parameters. METHODS:Totally 108 specimens of colorectal carcinoma resected by operation or with biopsy through enteroscope were collected from the Affiliated Hospital of Guilin Medical College from October 1996 to October 2002.The expressions of MMP 9 and TIMP 2 proteins in the 108 cases of colorectal carcinoma were detected by S P immunohistochemical method. RESULTS:The positive expression rates of MMP 9 and TIMP 2 in the 108 cases of colorectal carcinoma were 60.2% (65/108) and 25.0% (27/108) respectively.The expression of MMP 9 in colorectal cancers was high in the patients with invading depth,lymph node metastasis,Duke's stages and shorter survival time(P< 0.0001).The expression of TIMP 2 in these cases was just opposite.However,the expressions of MMP 9 and TIMP 2 have no relationship with gender,age,tumor site,pathological types and differentiation grade(P > 0.05). CONCLUSION:MMP 9 and TIMP 2 are the important and suggestive factors for judging tumor degree,metastasis and prognosis in colorectal carcinoma.
出处
《中国临床康复》
CSCD
北大核心
2005年第6期112-113,共2页
Chinese Journal of Clinical Rehabilitation
