摘要
目的:研究有丝分裂活化蛋白激酶ERK表达与口腔鳞癌(OSCC)临床分期、癌细胞分化程度及淋巴结转移的关系。方法:采用SP免疫组织化学方法检测41例OSCC组织中ERK蛋白的表达,数据采用t检验进行显著性比较,Logistic回归分析。结果:ERK蛋白表达强度随OSCC临床分期的提高而增强(P<0.01);OSCC中ERK蛋白表达强度与淋巴结转移密切相关(P<0.05);OSCC中ERK蛋白表达强度与癌细胞分化程度无关(P>0.05)。结论:ERK蛋白表达与口腔鳞癌的发生及进展密切相关,是患者预后的重要指标之一。
PURPOSE: To study the relationship between the expression of extracellular signal-regulated protein kinase (ERK) and the differentiation degree and lymphnode metastasis in oral squamous cell carcinoma. METHODS: Immunohistochemical staining was used in 41 cases of OSCC to investigate the expression of ERK protein. Student's t test were used for statistical analysis. RESULTS: A significant relationship was observed between the expression intensity of ERK protein and clinicopathological features of OSCC(P<0.01). A significant relationship was observed between the expression intensity of ERK protein and lymph node metastasis of OSCC(P<0.05). No correlation between the expression intensity of ERK protein and cell differentiation degree of OSCC(P>0.05) was found. CONCLUSIONS: Activation of ERK may play a strong role in the development of OSCC. Intensive expression of ERK protein may be an important presage marker in OSCC patients.
出处
《上海口腔医学》
CAS
CSCD
2005年第1期18-20,共3页
Shanghai Journal of Stomatology
