摘要
背景与目的:肝脏原发淋巴瘤(primaryhepaticlymphoma,PHL)是临床上极为罕见的恶性肿瘤,国内外相关文献报道不多。本文旨在初步探讨PHL的临床病理特点和治疗。方法:对近十年来中山大学肿瘤防治中心收治的4例PHL患者的临床资料进行总结分析。结果:本组病例中,男性3例,女性1例,患者中位年龄53岁;单发病灶3例,多发病灶1例;4例均有HBV指标阳性;3例术前误诊,1例术前未能确诊;3例为非霍奇金淋巴瘤,且均为B细胞性,1例为霍奇金淋巴瘤;2例行手术切除,另2例仅行活检;术后均行全身辅助化疗。结论:PHL可能与HBV病毒感染有关;对于伴有B症状的肝内占位性病变要怀疑PHL的可能性;手术切除辅助CHOP方案化疗是目前较为理想的治疗方法。
BACKGROUND & OBJECTIVE: Primary hepatic lymphoma (PHL), a rare malignancy, has seldom been reported. This article was to investigate clinicopathologic features and treatment of PHL. METHODS: Data of 4 patients with PHL, treated in Cancer Center, Sun Yat-sen University from Nov. 1994 to May 2004, were retrospectively analyzed. RESULTS: Of the 4 patients, 3 were men, and 1 was woman, with a median age of 53 years old; 3 had single focus, and 1 had multi-foci. All patents were positive for HBV antigen, 3 were misdiagnosed preoperatively, and 1 had no clear diagnosis before operation. Pathologic examination revealed that 3 were B-cell non-Hodgkin?蒺s lymphoma, and 1 was Hodgkin's lymphoma. Two patients received resection, and 2 received biopsy; all patients received adjuvant chemotherapy postoperatively. CONCLUSIONS: HBV infection might relate with the development of PHL. PHL should be considered for the patients presented liver mass and B-symptomatolgy. Resection followed by adjuvant chemotherapy with CHOP regiment seems to be the best option for PHL.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2005年第3期365-367,共3页
Chinese Journal of Cancer
关键词
肝脏
淋巴瘤
诊断
治疗
Liver
Lymphoma
Diagnosis
Therapy
