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心脏中的T型钙通道 被引量：1

Cardic T-type Calcium Channel
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摘要 T型钙通道被认为在心脏自律性、细胞生长和心血管重塑中起关键性的作用 ,一直是研究的热点。目前三种编码T型钙通道的基因已经被确定 ,但是这些T型钙通道的天然构型尚未被确定。文章从分子结构。 T-type Ca 2+ channels have been suggested to play a role in cardiac automaticity, cell growth, and cardiovascular remodeling. Although three genes encoding for the T-type Ca 2+ channel have been identified, the nature of the isoforms supporting the cardiac T-type Ca 2+ current has not yet been determined. We review the circumstances of the research of T type calcium channel in the molecular structure, function and regulation.
作者 李沪生 刘远谋
机构地区 上海第二医科大学基础医学院生理学教研室
出处 《上海第二医科大学学报》 CSCD 北大核心 2005年第2期188-190,共3页 Acta Universitatis Medicinalis Secondae Shanghai
基金 国家自然科学基金 (30 2 70 4 98) 上海市卫生局基金 (0 2 4 0 78)资助项目
关键词 T型钙通道 心脏 心血管重塑 细胞生长 天然 基因 关键性 调控 分子结构 构型 T- type calcium channel cardiac Cav family
分类号 R331.36 [医药卫生—人体生理学]
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参考文献20

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同被引文献26

  • 1刘国树.钙离子通道阻滞剂治疗高血压病新进展[J].中国药物应用与监测,2006,3(4):1-4. 被引量：10
  • 2张志国,张庆柱.T型钙通道及其作用药物研究进展[J].中国药理学通报,2007,23(2):143-147. 被引量：10
  • 3刘元生,郭继鸿,张海澄,李学斌,许原,张幼贻,袁兰.犬心房颤动时T型钙通道在心房电重塑中的作用及机制探讨[J].中国实用内科杂志,2007,27(12):929-931. 被引量：7
  • 4Miler R J.Rocking and rolling with Ca2+ channels[J].Trends Neurosci,2001,24(8):445-449.
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  • 6Chung O,Hinder M,Sharma A M,et al.Comparison of the efficacy and safety of losartan (50-100 mg) with the T-type calcium channel blocker mibefradil (50-100 mg) in mild to moderate hypertension[J].Fundam Clin Pharmacol,2000,14(1):31-41.
  • 7JATOS Study Group.The Japanese Trial to Assess Optimal Systolic Blood Pressure in Elderly Hypertensive Patients (JATOS):protocol,patient characteristics,and blood pressure during the first 12 months[J].Hypertens Res,2005,28(6):513-520.
  • 8Ohashi N,Mitamura H,Ogawa S.Development of newer calcium channel antagonists:therapeutic potential of efonidipine in preventing electrical remodelling during atrial fibrillation[J].Drugs,2009,69(1):21-30.
  • 9Mulder P,Richard V,Compagnon P,et al.Increased survival after long-term treatment with?mibefradil,a selective T-channel calcium antagonist,in heart failure[J].J Am Coll Cardiol,1997,29(2):416-421.
  • 10Levine T B,Bernink P J,Caspi A,et al.Effect of mibefradil,a T-type calcium channel blocker,on morbidity and mortality in moderate to severe congestive heart failure:the MACH-1 study.Mortality Assessment in Congestive Heart Failure Trial[J].Circulation,2000,101(7):758-764.

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上海第二医科大学学报
2005年 第2期

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