摘要
目的:探讨酒精性肝硬化(ALC)合并肝炎病毒感染的临床发病特点。方法:对我院1994年至2003年收治的237例ALC患者的临床资料进行分析。结果:237例ALC患者合并肝炎病毒感染79例(33.3%),其中乙肝病毒感染67例(28.3%),丙肝病毒(HBV)感染8例(3.4%),乙肝与丙肝病毒混合感染4例(1.7%),无肝炎病毒感染158例(66.7%);感染组的出血和肝性脑病发生率与非感染组相比差异显著(P<0.025);感染组血清AST、ALT明显升高的比率分别是38%和22.8%,非感染组分别是22.8%、8.8%,两组比较差异显著(P<0.025);感染组肝癌的发生率为19.3%,而非感染组仅为1.9%,两组比较差异显著(P<0.01)。结论:酒精与肝炎病毒在肝损伤过程中起协同作用,肝炎病毒感染增加了ALC肝癌发生的机会。
Objective To explore the clinical characteristics of ALC cases infected with hepatitis viruses. Method 237 ALC cases from 1994 to 2003 were analyzed. Results 79 of 237 ALC cases (33.3%) were infected with hepatitis viruses, among which, 67 were infected with HBV , 8 HCV, and 4 coinfected with HBV and HCV. The significant deviation was shown in incidence rate of upper gastrointestinal hemorrhage and hepatic encephalopathy between infected group and non-infected group (P<0.025). AST and ALT rised greatly in 38% and 22% patients in infected group, while in non-infected group, they were 22.8% and 8.8%. AST and ALT raised more greatly in infected group than in non-infected group. Significant deviation was shown in the incidence rate of hepatic cellular cancer (HCC) between infected group (19.3%) and non-infected group (1.9%). Conclusion Alcoholic and hepatitis viruses play a role of synergistic action in causing damage to liver. ALC patients infected with hepatitis viruses were easy to develop hepatic cellular cancer (HCC).
出处
《吉林医学》
CAS
2005年第2期158-159,共2页
Jilin Medical Journal
