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NBD多肽的临床应用研究进展 被引量：1

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摘要 核因子 κB(nuclearfactor κB ,NF κB )在免疫应答、炎症反应和细胞凋亡的过程中发挥着重要作用 ,已经成为相关疾病治疗的新靶点。NF κB必需调节蛋白结合区 (NF κBessentialmodifierbindingdomain ,NBD)多肽是仅有 6个氨基酸残基的小分子肽 ,它可以与IκB激酶 (IKK)的调节亚基 (NF κBessentialmodifier ,NEMO)结合 ,阻止IKK激活 ,从而选择性地抑制NF κB的过度表达。将对许多炎症性疾病、免疫性疾病和肿瘤的治疗起到重要作用。
作者 刘学进 陈垦
机构地区 广东医学院附属医院消化科 广东药学院临床医学系
出处 《国外医学（生理病理科学与临床分册）》 2004年第6期527-530,共4页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
基金 广东药学院科技处基金立项课题 (5 13 42 0 0 1)
关键词 核因子-ΚB NF-κB必需调节蛋白结合区(NBD) 多肽
分类号 R96 [医药卫生—药理学]
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参考文献18

  • 1Choi M, Rolle S, Wellner M, et al. Inhibition of NF-kappa B by a TAT-NEMO-binding domain peptide accelerates constitutive apoptosis and abrogates LPS-delayed neutrophil apoptosis [ J ]. Blood,2003,102 (6): 2259-2267.
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同被引文献12

  • 1王文良,姜文学,杨柳,吴岳嵩.人工关节松动的生物学因素:细胞因子和人工关节骨溶解[J].中国临床康复,2004,8(26):5632-5634. 被引量：4
  • 2Harris W H. Wear and periprosthetic osteolysis: the problem[ J]. Clin Orthop Relat Res, 2001, (393) : 66 -70.
  • 3Simonet W S, Lacey D L, Dunstan C R, et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density [ J ]. Cell, 1997, 89(2) : 309 -319.
  • 4Epstein N J, Warme B A, Spanogle J, et al. Interleukin-1 modulates periprosthetic tissue formation in an intramedullary model of particle-induced inflammation[J]. J Orthop Res, 2005, 23(3): 501 -510.
  • 5Chen X, Ji B, Han B, et al. NF-kappaB activation in pancreas induces pancreatic and systemic inflammatory response [ J ]. Gastroenterology, 2002, 122(2) : 448 -457.
  • 6Haeberle H A, Casola A, Gatalica Z, et al. IkappaB kinase is a critical regulator of chemokine expression and lung inflammation in respiratory syncytial virus infection[ J]. J Virl, 2004, 78 (5) : 2232 - 2241.
  • 7Heussler V T, Rottenberg S, Schwab R, et al. Hijacking of host cell IKK signalosomes by the transforming parasite theileria [ J ]. Science, 2002, 298(5595) : 1033 - 1036.
  • 8Choi M, Rolle S, Wellner M, et al. Inhibition of NF-kappaB by a TAT-NEMO-binding domain peptide accelerates constitutive apoptosis and abrogates LPS-delayed neutrophil apoptosis [ J ]. Blood, 2003, 102(6) : 2259 -2267.
  • 9Carter R S, Pennington K N, Ungurait B J, et al. In vivo identification of inducible phosphoacceptors in the IKKgamma/NEMO subunit of human IkappaB kinase[ J]. J Biol Chem, 2003, 278(22) : 19642 - 19648.
  • 10陶崑,沈灏,张先龙,王琦,邵俊杰,彭晓春.红霉素和阿伦磷酸钠防治人工关节松动动物实验研究[J].中国矫形外科杂志,2008,16(17):1343-1346. 被引量：11

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国外医学（生理病理科学与临床分册）
2004年 第6期

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