摘要
目的 观察利培酮治疗老年期精神分裂症的疗效及安全性。方法 对32例老年期精神分裂症患者应用利培酮治疗, 疗程8w,分别在治疗前及治疗第2、4、6、8w末采用阳性与阴性症状量表、副反应量表评定疗效和不良反应。疗效评定标准: 阳性与阴性症状量表减分率>75%为痊愈,50～75%为显著进步,25～49%为好转,<25%为无效。结果 治疗8w末阳性与 阴性症状量表减分率为65.3±16.4,与治疗前比较差异有极显著性(P<0.01),总有效率为84.4%。不良反应较轻,主要有 口干、头昏、视物模糊、心动过速等。结论 利培酮治疗老年期精神分裂症疗效较好,且安全性高,可作为一线药物应用。
Objective To explore curative effects and safety of risperidone in the treatment of senile schizophrenics. Methods 32 senile schizophrenics were treated with risperidone for 8 weeks.Efficacy and side effects were assessed with the Positive and Negative Symptoms Scale(PANSS) and Treat ment Emergent Symptoms Scale(TESS) before treatment and at the ends of 2 nd,4 th,6 th and 8 th week,respectively.Criterion of curative effect:score-reducing rate >75% was recovery,50~75% significant improvement,25~49% improvement and <25% ineffectiveness. Results After 8 week treatment, score-reducing of the PANSS was 65.3±16.4%, compared with rate pre-treatment difference was significant(P<0.01) and total effective rate 84.4%.Side effects were milder and mainly dry mouth, dizziness, vision vague , tachycardia etc. Conclusion Risperidone has better curative effect and higher safety in the treatment of senile schizophrenics.
出处
《临床心身疾病杂志》
CAS
2005年第1期33-34,共2页
Journal of Clinical Psychosomatic Diseases
关键词
老年期
精神分裂症
利培酮
Geratic period
schizophrenia
risperidone
