摘要
目的 探讨β 纤维蛋白原(Fg)启动子区-148C/T基因多态性、血浆Fg水平与青年急性脑梗 死(ACI)的关系。方法 用多聚酶链反应 限制性片段多态性方法对69例青年ACI患者进行β Fg-148C/T 基因多态性分析,应用凝血酶原时间衍生法检测血浆Fg水平,并与60名健康青年进行对照。结果 青年 ACI组血浆Fg水平明显高于对照组(P<0.01);T等位基因携带者较CC基因型者血浆Fg明显增高(P< 0.05);T等位基因频率在两组分别为21.7%和16.7%,差异无显著性(P>0.05)。结论 β Fg-148C/T基 因多态性影响血浆Fg水平,T等位基因可能通过与其他血栓危险因素或环境因素协同作用增高血浆Fg水 平。
Objective To study the association between -148C/T polymorphism of β-fibrinogen gene and plasma fibrinogen levels in young patients with acute cerebral infarction(ACI).Methods 69 young patients with ACI and 60 young healthy individuals were enrolled in this trial. The β-fibrinogen gene-148C/T polymorphism was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and plasma fibrinogen levels were obtained from prothrombin time assay.Results Plasma fibrinogen levels of the patients were significantly higher than those of the controls ( P<0.01). In both groups those with T allele had higher plasma fibrinogen levels than those without ( P>0.05), but there was no significant difference in T allele frequencies between the patients and the controls ( P>0.05).Conclusions Plasma fibrinogen level is affected by -148C/T polymorphism of β-fibrinogen gene. High plasma fibrinogen level is a risk factor for ACI in Chinese young adults. With other risk factors and environmental factors, T allele increases plasma fibrinogen level and may be a heritable risk factor for ACI in Chinese young adults.
出处
《临床神经病学杂志》
CAS
北大核心
2005年第1期40-42,共3页
Journal of Clinical Neurology
关键词
急性脑梗死
纤维蛋白原
基因多态性
acute cerebral infarction
fibrinogen
gene polymorphism
