摘要
目的:探讨从压力负荷增加到心肌肥厚形成的整个过程中血清肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)、白介素-6(IL-6)的变化及意义。方法:采用放射性免疫法检测腹主动脉部分结扎大鼠不同时间点血清TNF-α、IL-1β、IL-6的浓度,电子天平称量左心室重,计算心重指数(左心重mg/体重g)。结果:与对照组相比,心肌肥厚大鼠血清TNF-α、IL-1β、IL-6升高,且与心肌肥厚程度正相关。结论:细胞因子可能参与了心肌肥厚的发生和发展。
Objective:to investigate the significane of changes in serum tumor necrosis factor - α(TNF-α) ,interleukin 1β(IL-1β)and interleukin - 6(IL -6) from the increase in load to hypertrophy. Methods: the partial abdominal aorta ligature was used to induce hypertrophy in rats. Serum TNF-α,IL-1β and IL-6 levels were determined with radioimmunological assay. The left ventricule was weighed with electronic balance . Results :Compared with the control rats,serum TNF - α,IL - 1β and IL - 6 increased greatly in rats with left ventricular hypertrophy. There was direct correlation of serum TNF - α,IL-1β and IL - 6 with degree of left ventrical hypertrophy. Conclusion:Cytokine may play a important role in the development and progression of left ventricular hypertrophy.
出处
《包头医学院学报》
CAS
2004年第4期268-270,共3页
Journal of Baotou Medical College
