摘要
目的:探讨血清视黄醇结合蛋白(retinol- binding protein,RBP)在慢性肾小球肾炎中的诊断价值。方法:分别采用生化比色和免疫法测定5 6例慢性肾小球肾炎血清RBP、β2 微球蛋白(β2 - MG)、尿素(Urea)、肌肝(Cr)含量。结果:5 6例慢性肾小球肾炎患者血清RBP含量为(86 .5 2±36 .5 0 ) mg/ L ,β2 - MG为(2 84 7.2 1±2 5 8.5 3) mg/ L ,Urea为(10 .35±3.6 2 ) m g/ L,Cr为(2 5 7.4 3±98.6 4 ) mg/ L 。对照组分别为(49.6 5±13.82 ) mg/ L、(76 6 .2 6±10 8.6 1) mg/ L、(5 .12±0 .98) mg/ L和(6 8.11±2 3.6 0 ) mg/ L。它们两两间存在显著差别(P<0 .0 5 )。慢性肾小球肾炎血清RBP与β2 - MG、Urea、Cr间存在较好的相关性。结论:RBP可以作为反映慢性肾小球肾炎肾功能异常的较敏感指标。并且RBP和β2 -MG间的相关性最好。
Objective To explore the value of serum retinol-binding protein(RBP)in chronic glomerulonephritis.Methods Biochemical and immunological methods were used to assay serum RBP,β 2-MG, Urea, Cr of fifty-six patients with chronic glomerulonephritis.Results Serum RBP,β 2-MG, Urea, Cr levels were(86.52±36.50) mg/L,(2 847.21±258.53) mg/L, (10.35±3.62) mg/L,(257.43±98.64) mg/L respectively in patients with chronic glomerulonephritis the healthy control group were(49.65±13.82) mg/L, (766.26±108.61) mg/L, (5.12±0.98) mg/L和(68.11±23.60) mg/L respectively?There were significantly difference between two groups(P<0.05).Also there were correlation among renal function indices of patients group.Conclusion We suggest that RBP may be better index in evaluating the damage of kidney in chronic glomerulonephritis. Furthermore, RBP was correlated with β 2-MG significantly.
出处
《实用医技杂志》
2005年第01B期173-175,共3页
Journal of Practical Medical Techniques
