摘要
目的 :探讨原发性甲状腺功能减退症 (甲减 )患者血清胰岛素样生长因子 1 (IGF 1 )和胰岛素样生长因子结合蛋白 3(IGFBP 3)水平的变化。方法 :采用放射免疫分析法 (RIA)检测 2 0例经左旋甲状腺素治疗前后甲减患者和 2 0名健康人 (对照组 )血清IGF 1和IGFBP 3水平。结果 :甲减治疗前 ,血清IGF 1水平 (1 2 3.1± 36 .4 )ng/ml,IGFBP 3水平 (1 898± 6 30 )ng/ml明显低于对照组 [IGF 1水平 (2 70 .7± 5 0 .1 )ng/ml、IGFBP 3水平 (342 5± 935 )ng/ml],差异有显著性 (P <0 .0 1 ) ;甲减治疗后 ,大多数甲减缓解患者血清IGF 1和IGFBP 3水平得到恢复 ,IGF 1水平 (2 39.4± 4 5 .6 )ng/ml、IGFBP 3水平 (31 6 7± 86 6 )ng/ml明显高于治疗前 (P <0 .0 1 ) ,而且与对照组比较 ,差异无显著性 (P >0 .0 5 )。结论 :甲减患者血清IGF 1和IGFBP 3水平明显下降 ,两者的正常调节均可能受甲状腺激素变化的影响。
Objective:To study the changes of serum insulin-like growth factor-1(IGF-1) and insulin-like growth factor binding protein-3(IGFBP-3) levels in primary hypothyroidism.Methods:The serum IGF-1 and IGFBP-3 levels were determined with radio-immunologic assay(RIA) in 20 cases of patiens whose before and after completion of therapy with L-thyroxine in primary hypothyroidism and 20 cases of normal controls.Results:The serum IGF-1 levels(123.1±36.4)ng/ml and IGFBP-3 levels(1898±630)ng/ml in hyperthyroidism were significantly lower than that of IGF-1 levels(270.7±50.1)ng/ml and IGFBP-3 levels(3425±935)ng/ml in controls(P<0.01). The serum IGF-1 levels(239.4±45.6)ng/ml and IGFBP-3 levels(3167±866)ng/ml in hypothyroidism patients after treatment were significantly higher than those before treatment(P<0.01) and there was no statistical difference compared with controls(P>0.05).Conclusion:The levels of serum IGF-1 and IGFBP-3 in hypothyroidism markedly descend and the normal regulation of IGF-1 and IGFBP-3 levels may be influenced significantly by changes of thyroid hormone levels.
出处
《温州医学院学报》
CAS
2005年第1期41-42,45,共3页
Journal of Wenzhou Medical College
