摘要
目的 :探讨nm2 3-H1、P53 、PCNA的表达与舌鳞状细胞癌淋巴结转移的关系。方法 :应用免疫组化SP法 ,检测 18例淋巴结转移组和 5 7例非淋巴结转移组肿瘤原发灶中nm2 3-H1、P53 、PCNA的表达分布情况。结果 :nm2 3-H1在非淋巴结转移组中的阳性率 (86 .0 % )显著高于淋巴结转移组 (2 7.8% ) ,与转移呈负相关 (P <0 .0 5 ) ;淋巴结转移组中的P53 阳性率 (77.8% )和PCNA阳性指数 (91.2± 3.4 % )显著高于非淋巴结转移组 (38.6 %、70 .7± 2 .2 % ) ,与转移呈正相关 (P <0 .0 5 )。结论 :nm2 3-H1、P53 、PCNA的表达水平可作为预测舌鳞状细胞癌淋巴结转移情况的有效指标。
Objective: To investigate the relationship of nm23-H 1、P 53 and PCNA expression with lymph node metastasis of tongue squamous cell carcinoma(TSCC). Methods: The expression of nm23-H 1、P 53 and PCNA in primary tumors of 18 cases of lymph node metastasis group and 57 cases of non-lymph node metastasis group was detected by immunohistochemical technique(SP method). Results: The positive rate of nm23-H 1 in non-lymph node metastasis group(86.0%) was significantly higher than in lymph node metastasis group(27.8%). There was a negative correlation between nm23-H 1 expression level and lymph node metastasis(P<0.05). The positive rate of P 53 and positive index of PCNA in lymph node metastasis group(77.8% and 91.2±3.4% respectively) was significantly higher than in non-lymph node metastasis group(38.6% and 70.7±2.2% respectively), and positive expression of P 53、PCNA was positively correlated to lymph node metastasis(P<0.05). Conclusions: nm23-H 1、P 53、PCNA expression level may be the reliable markers for predicting lymph node metastasis of TSCC.
出处
《口腔医学研究》
CAS
CSCD
2004年第6期604-606,共3页
Journal of Oral Science Research
