期刊文献+

中性内肽酶及其抑制剂在心血管疾病过程中的作用 被引量:3

Protective role of neutral endopeptidase in cardiovascular diseases
下载PDF
导出
摘要 中性内肽酶是一种属于Ⅱ型跨膜蛋白的肽类内切酶 ,在肽链的氨基端水解疏水氨基酸肽键 ,灭活心钠素、肾上腺髓质素、血管紧张素、内皮素等心血管活性肽 ,在高血压病、心力衰竭。
出处 《生理科学进展》 CAS CSCD 北大核心 2005年第1期53-54,共2页 Progress in Physiological Sciences
基金 国家重大基础研究发展规划 (973)项目资助课题(G2 0 0 0 0 5 6 90 5 )
  • 相关文献

参考文献9

  • 1Roques BP. Cell surface metallopeptidases involved in blood pressure regulation: Structure, inhibition, and clinical perspectives. Path Biol, 1998,46: 191 ~200.
  • 2Roques BP, Noble F, Dauge V, et al. Neutral endopeptidase 24. 11: Structure, inhibition, and experimental andclinical pharmacology. Pharmacol Rev, 1993,45 : 87 ~146.
  • 3Vishwanatha JK, Davis RG, Blumberg S, et al. Increased tissue neutral endopeptidase 24.11 activity in spontaneously hypertensive hamsters. Am J Hypertens, 1998,11:585 ~590.
  • 4Lightner AM, Jordan TH, Bunnett NW, et al. Recombinant human neutral endopeptidase ameliorates pancreatic elastaseinduced lung injury. Surgery, 2002,132: 193 ~ 199.
  • 5Fielitz J, Dendorfer A, Pregla R, et al. Neutral endopeptidase is activated in cardiomyocytes in human aortic valve stenosis and heart failure. Circulation, 2002,105 : 286 ~289.
  • 6Walther T, Siems WE, Hauke D, et al. AT1 receptor blockade increases cardiac bradykinin via neutral endopeptidase after induction of myocardial infarction in rats. FASEBJ, 2002,16: 1237 ~ 1241.
  • 7Backlund T, Palojoki E, Saraste A, et al. Effect of vasopeptidase inhibitor omapatrilat on cardiomyocyte apoptosis and ventricular remodeling in rat myocardial infarction. Cardiovasc Res, 2003,57: 727 ~737.
  • 8Rademaker MT, Charles C J, Cooper GJ, et al. Combined endopeptidase inhibition and adrenomedullin in sheep with experimental heart failure. Hypertension, 2002,39 : 93 ~98.
  • 9Grantham JA, Schirger JA, Wennberg PW, et al. Modulation of functionally active endothelin-converting enzyme by chronic neutral endopeptidase inhibition in experimental atherosclerosis. Circulation, 2000,101: 1976 ~ 1981.

同被引文献52

引证文献3

二级引证文献12

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部