摘要
目的 :探讨 p5 3在甲状腺肿瘤中的表达意义。 方法 :用免疫组化SP法 ,检测 30例甲状腺良性病变、10 0例甲状腺癌中 p5 3的表达。结果 :p5 3在正常甲状腺组织呈阴性表达 ,在甲状腺腺瘤、结节性甲状腺肿、甲状腺乳头状癌、滤泡癌、未分化癌表达阳性率分别为 13.3%、13.3%、36 .4 %、4 2 .9%、4 6 .2 % ,与组织学类型密切相关 (P <0 .0 0 1) ,其中良恶性病变之间差异有显著性 (P <0 .0 5 )。结论 :p5 3是鉴别甲状腺良恶性肿瘤及判断其生物学行为的重要指标。
Objective: To study the significance of the expression of p53 in thyroid carcinoma.Method: Immunohistochemistry was used to detect the expression of p53 in 10 normal thyroid tissues, 30 thyroid benigh disease and 100 thyroid carcinoma. Result: No positive expression of p53 was found in normal thyroid tissues. The positite rate of p53 in thyroid adenoma, nodular goitre, papillary thyroid carcinoma, follicular thyroid carcinoma and undefferentediated carcinoma was 13.3%、13.3%、36.4%、42.9%、46.2% respectively. The expression of p53 was significantly correlated with the various pathologic types of them (P<0.001). Significantly differences of p53 expression can be seen between thyroid benigh and maligant tumor (P<0.05). Conclusion: p53 expression can be important factors for identifying the benigeh and maligant tumor and their biological behaviors.
出处
《河北医学》
CAS
2005年第1期24-26,共3页
Hebei Medicine
