摘要
目的 :研究盐酸氨溴索对氨茶碱体内药动学是否有影响。方法 :将16名受试者随机分为试验组和对照组 ,采用高效液相色谱法测定氨茶碱血药浓度 ,用3p97程序计算药动学参数。结果 :试验组和对照组氨茶碱的Ke分别为 (0.062±0.023)、(0.0905±0.013)/h ;V分别为 (22.83±7.85)、(23.27±3.78)L ;T1/2 分别为 (12.51±4 2)、(7.77±0.89)h ;AUC0～21 分别为 (426.59±186.92)、(245.74±48.6) (mg·h)/L ;CL(s)分别为 (23.17±9.83)、(34.84±6.00)ml/min。结论 :盐酸氨溴索虽不影响氨茶碱在体内的分布 ,但可延长其半衰期 ,增加其在体内的滞留时间。
OBJECTIVE:To study whether there is interaction between ambroxol hydrochloride and aminoˉphylline.METHODS:16volunteer were randomly divided into trial group and control group.The blood concentration of amin_ ophylline was determinated with HPLC method,then the main parameters of pharmacokinetics of aminophylline were calculated with3p97software.RESULTS:The main parameters of pharmacokinetics of aminophylline in trial and control group were:K e (0.062±0.023)/h and(0.0905±0.013)/h;V(22.83±7.85)and(23.27±3.78)L;T 1/2 (12.51±4.2)and(7.77±0.89)h;AUC 0～21 (426.59±186.92)and(245.74±48.6)(mg·h)/L;CL(s)(23.17±9.83)and(34.84±6.00)ml/min respectiveˉly.CONCLUSION:Although ambroxol hydrochloride did not influence the distribution of aminophylline,but it could prolong the half time of aminophylline and increase the stagnation time of aminophylline in vivo.
出处
《中国药房》
CAS
CSCD
北大核心
2005年第2期124-126,共3页
China Pharmacy
