甲泼尼龙在神经外科领域的应用
摘要
与其它糖皮质激素不同，甲泼尼龙是目前临床上治疗急性脊髓损伤的有效药物，主要通过抑制氧自由基诱导的脂质过氧化发挥神经保护作用。甲泼尼龙对中枢神经系统肿瘤、蛛网膜下腔出血也有一定的治疗效果，可作为手术、放、化疗的辅助用药。但甲泼尼龙对急性颅脑损伤是否同其治疗脊髓损伤一样有效，尚不十分清楚。
出处
《国外医学（神经病学．神经外科学分册）》
2004年第6期568-571,共4页
Foreign Medical Sciences（Section On Neurology & Neurosurgery）
参考文献25
-
1Brachen MB,Collins WF,Freeman DF,et al.Efficacy of Methylprodnisolone in acute spinal cord injury.JAMA,1984,251(1):45-52.
-
2Bracken MB, Shepard MJ, Collins WF, et al. A randomized, controllled trial d methyllxednisolone or naloxone in the Weatmmt d acute spinal cord injmy. Results dthe Second Nstional Acute Splnal Cord Injury Study.N Engl J Med, 1990, 322(20): 1405- 1411.
-
3Bracken MB, Shepard MJ, Collins WF, et al. Methylprednimlene or naloxone treatment after acute spinal cold injury: 1 - year follow - up data. Results of the second National Acute Spinal Cord Injury Study. J Nenmsurg, 1992, 76(1): 23-31.
-
4Bracken MB, Shepard 1KI, Holford TR, ctal. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesytate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial.National Acute Spinal Cord Injury Study..JAMA, 1997, 277 ( 20 ) :1597 - 1604.
-
5Bracken MB, Shepard MJ, Holford TR, et el. Methylprednimlone or tirilazad mesylate administration after acute spinal cord injury: 1 - year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial. J Neurosurg, 1998, 89(5) : 699-706.
-
6Sekhm IB,Fddings MG.Epidemiology,denographics,and pathophysiology of acute spinal cord injury. Spine, 2fl01, 26(24 Suppl) : S2 - S12.
-
7Hall ED. The neuroprotective pharmacology of methylprednisolone. J Neurosurg, 1992, 76(1): 13-22.
-
8Bay SK,grllford GG, Matzlle DC,et al. Calpelxin and methyprednisolone inhibit apoptmls in rat spinal co rd injury. Arm N Y Acad Sci, 1999, 8g0:261.
-
9Xu J, Fan G, Chen S, et al. Methylprednisolone inhibition d TNF-alpha expression and NF - kB activation after spinal cord injury in rats.Brain Res Mol Brain Res, 1998, 59(2): 135 - 142.
-
10McCutchcon EP, Selassie AW, Gu JK, et al. Acute tra,matlc spinal cord injury, 1993 - 2000A population - based assessment of methylpradnisolone administration and hospitalization. J Trauma, 2004,56(5) : 1076 - i083.
-
1青格勒泰,张俊义,王新亮.糖皮质激素在神经外科中的应用及展望[J].疾病监测与控制,2012,6(2):84-86. 被引量：3
-
2国家自然科学基金引领中枢神经系统肿瘤的探索之路[J].中国现代神经疾病杂志,2009,9(6):519-521. 被引量：1
-
3肖玮,王天龙,赵磊,张婷.择期神经外科手术术后镇痛及不良反应的回顾性研究[J].中国现代神经疾病杂志,2011,11(4):453-457. 被引量：6
-
4杨纯正,熊冬生,许元富,齐静,高赢岱,谭耀红,邵晓枫,杨铭,范冬梅,薛艳萍,刘汉芝.血液肿瘤耐药机制及克服耐药研究[J].医学研究通讯,2005,34(7):31-32.
-
5孟然,周晋,王德生,李国忠,戚基萍,杨宝峰.甘露醇暂时渗透性开放血脑屏障的研究[J].中风与神经疾病杂志,2003,20(4):350-352. 被引量：23
