摘要
己酮可可碱(pentoxifylline PXFL)又称oxpe-ntifylline,商品名trental-400,为一、二甲基黄嘌呤衍生物及其代谢物,用于治疗外周循环障碍性疾病疗效满意。本文简介其药理学,药代动力学及临床应用,供临床参考。
出处
《新医学》
1993年第11期598-599,共2页
Journal of New Medicine
参考文献2
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同被引文献13
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1病毒性肝炎防治方案（试行）[J].中华传染病杂志,1995,13(4):241-247. 被引量：1767
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2钱绍诚.肝纤维化（肝硬化）的可逆性[J].中华消化杂志,1995,15(5):251-252. 被引量：134
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3吴升华.己酮可可碱的药理作用及其应用[J].临床荟萃,1996,11(9):404-406. 被引量：7
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4孟家眉.对脑卒中临床研究工作的建议[J].中华神经精神科杂志,1988,21:57-58.
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5Peterson TC. Pentoxifylline prevents fibrosis in an animal model and inhibits platelet-derived growth factor-driven proliferation of fibroblasts. Hepatology, 1993, 17: 486～ 93.
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6Peterson TC,Neumeister M. Effect of pentoxifylline in rat and swine models of hepatic fibrosis: role of fibroproliferation in its mechanism. Immunopharmacology, 1996, 31(2～3):183～93.
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7Li D, Friedman SL. Liver fibrogenesis and the role of hepatic stelate cells: New insight and prospects for therapy. J Gastroenterol Hepatol, 1999, 14: 618～ 33.
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8Nozaki K, Egawa H, Bermudez, L, et al .Effects of pentoxifylline pretreatment one kupffer cells in rat liver transplantation. Hepatology, 1995, 21(4):1079～82.
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9Kubo Y, Yasunaga M, Masuhara M, et al. Hepatocyte proliferation induced in rats by lead nitrate is suppressed by several tumor necrosis factor alpha inhibitors. Hepatology, 1996, 23(1):104～14.
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10Berman B, Duncan MR. Pentoxifylline inhibits normal human dermal fibroblast in vitro proliferation, collagen, glycosamino glycan, and fibronectin production, production, and increases collagenase activity. J Invest Dermal, 1989, 92: 605～ 10.
引证文献3
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1朱玉琴.己酮可可碱治疗急性眩晕疗效观察[J].护理学杂志,2006,21(7):17-17.
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2朱瑞财,李桂荣.己酮可可碱治疗急性缺血性脑梗塞[J].现代中西医结合杂志,1999,8(10):1601-1602.
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3吕洪敏,向慧玲,李岩,钱绍诚.己酮可可碱抗肝纤维化作用的临床实验研究[J].天津医药,2003,31(2):112-113. 被引量：4
二级引证文献4
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1吴雄健,舒建昌.己酮可可碱抗肝纤维化作用的研究[J].广东药学院学报,2005,21(2):203-204. 被引量：1
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2范建高,钱燕.已酮可可碱对大鼠非酒精性脂肪性肝炎保护机制的探讨[J].中华消化杂志,2008,28(1):50-51. 被引量：3
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3李金科,李芳,朱琳,占国清,胡波,李刚.己酮可可碱治疗慢性乙型肝炎肝纤维化临床观察[J].山西医药杂志（上半月）,2009,38(8):752-753.
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4刘立平.我国慢性乙型肝炎抗纤维化的临床药物治疗[J].中国保健营养（下半月）,2010(6):10-11.
