摘要
目的 :回顾性分析比较不同方式治疗鼻咽癌患者的远期疗效 ,并分析其它相关因素对其预后的影响。方法 :从 1988年 1月至 1996年 3月共收治住院 895例首程根治鼻咽癌患者。根据不同的治疗方法 ,分为常规放疗组、腔内放疗组、超分割放疗组和同期放化疗组。结果 :(1)本组病例总的 5年生存率为 5 0 6 4 % ,总的 10年生存率为 2 3 .2 9% ;其中常规组、腔内组、超分割组和同期放化疗组的 5年总生存率分别为 4 7. 33%、5 2. 6 7%、5 8. 82 %和 5 8 .85 % (P <0. 0 5 )。 (2 )Ⅰ、Ⅱ、Ⅲ、Ⅳ期病例的 5年总生存率分别为 88 89%、76 88%、5 6 . 6 7%和 31 .95 % (P <0 0 0 0 1)。 (3)局部控制率分别为 :常规组 83 95 %、腔内组 89. 4 0 %、超分割组 92. 4 5 %和放化疗组 96 . 0 6 %。 (4)用多因素逐步回归分析 ,N分期对生存率的影响最大 (P <0. 0 0 0 1) :不同的放疗方式及T分期对生存率亦有影响 (P <0 .0 5 ) ;加用化疗能提高生存率 (P <0 . 0 1)。结论 :采用不同的放疗方式 ,对生存率及局控率有影响 ;根治性放射治疗联合同期化疗对于N分期晚的鼻咽癌的远期疗效似有提高的趋势。
Objective:To retrospectively analyze and compare the long term results about the treatment for nasopharyngeal carcinoma by different methods and other prognostic factors.Methods:895 cases of nasopharyngeal carcinoma were treated from January 1988 to March 1996.Patients were divided in 4 groups which included conventional radiotherapy group(CRT),high dose rate brychetherapy irradiation group (HDR),hyperfractionated radiotherapy group(HFRT) and concurrent chemotherapy combined radiotherapy group(CHRT).Results:(1)The overall 5-year survival rates of the entire group was 50.64%,and 10-year survival rate was 23.29%.The total 5-year survival rate were 47.33% for CRT,52.67% for HDR,58.82% for HFRT and 58.85% for CHRT,respectively(P<0.05).(2)The 5-year survival rates for Ⅰ,Ⅱ,Ⅲ and Ⅳ stage were 88.89%,76.88%,56.67% and 31.95% respectively(P<0.0001).(3)The local control rate were 83.95% for CRT,89.40% for HDR,92.45% for HFRT and 96.06% for CHRT respectively.(4)The cox regression analysis showed that N staging had most prognostic effect on survival(P<0.05);survival was increased by combination with chemotherapy(P<0.01).Conclusion:Different radiotherapy methods may influence the survival and local control rates;radiotherapy combined with concurrent chemotherapy tend to improve the long term response of nasopharyngeal carcinoma,especially for patients with advanced N staging.
出处
《四川肿瘤防治》
2005年第1期12-14,共3页
Sichuan Journal of Cancer Control
关键词
鼻咽肿瘤
放射治疗
化学治疗
分割方式
鼻咽癌
Nasopharyngeal Neoplasms/Radiotherapy
Nasopharyngeal Neoplasms/Chemotherapy
Fractionation
Prognosis.
