摘要
目的探讨脑梗死急性期血小板活化在血栓形成中的作用。方法采用流式细胞术检测脑梗死患者全血标本血小板膜表面P-选择素(CD62P)与纤维蛋白原受体(FIB-R)的表达。结果与正常对照组比较,脑血栓形成组(例及腔隙性梗死组(例于发病后43)47)1～3d内CD62P与FIB-R的表达(阳性细胞百分率)均有显著性增高。脑血栓形成组FIB-R表达增加明显高于腔隙性梗死组,至病程第日7FIB-R表达增高仍有显著性差异。两患者组中发病前服用阿司匹林与否未见对检测结果有显著影响。结论脑血栓形成与腔隙性梗死急性期均存在血小板活化;阿司匹林对血小板膜表面表达CD62P及FIB-R无影响。
Objective To observe the status of platelets activation in cerebral infarction. Methods Flow cytometric immunofluorescence was used to check the molecular marker, the fibrinogen receptor (FIB-R) and P-selectin (CD62P) of circulating activated platelets in patients with acute cerebral infarction. Results Compared with normal control group, both the expressions of FIB-R and CD62P were significantly increased in patients with cerebral thrombosis (n = 43) and in patients with larcunar infarction (n = 47). The expression of FIB-R in patients with cerebral thrombosis was more common than that in patients with larcunar infarction, and the expression level remained high in the 7th day after the attack. There were no differences observed in platelet activation between the patients with or without oral aspirin prior to the attack. Conclusions Both CD62P and FIB-R are sensitive markers for detecting circulating activated platelets. Activated platelets exist in cerebral thrombosis and larcunar infarction as well.
出处
《北京医学》
CAS
2005年第2期92-94,共3页
Beijing Medical Journal
