摘要
灸甘草汤能降低大鼠心肌缺血再灌注诱发心律失常发生率；缩小再灌注后心肌梗墓范围，减少再灌注后心肌肌酸激酶和乳酸脱氢酶的释放以及减少脂质过氧化产物丙二醛的生成。提示炙甘草汤对心肌缺血再灌注损伤有保护作用。
his paper studied the influence of Zhi Gan Chao Decoction on the ischemic-reperfused injury in rat hearts induced by ligating left descending coronary artery for 30 minutes and then reperfusing it for 45 minutes. The results indicated that Zhi Gan Chao Decoction significantly reduced the incidence of arrhythmias induced by myocardial reperfusion in anesthetized rats and obviously decreased the infart size (IS). The results also showed that the Decoction reduced the release of myocardium creatine phosphokinase (CK) and lactate dehydrogenase (LDH) in myocardial cells, andthe production of toxic lipid peroxide malondialdehyde (MDA) after the ischemic-reperfusion.
出处
《中药药理与临床》
CAS
CSCD
1994年第5期6-8,共3页
Pharmacology and Clinics of Chinese Materia Medica
关键词
炙甘草汤
心肌缺血再灌注损伤
保护作用
脂质过氧化产物
诱发
肌酸激酶
心肌梗塞
降低
释放
生成
Zhi Gan Chao Decoction
Ischemic-repertusion
Arrhythmia
Myocardial infart size(IS)
Creatinephosphokinase (CK)
Lactate dehydrogenase (LDH)
malondialdehyde (MDA)
