摘要
用含胆固醇1％、胆盐0.25％、猪油5％的高脂饲料喂饲健康雄性大鼠,诱发高脂血症的同时分别加入5％的魔芋精粉、果胶、褐藻胶及琼脂,观察此四种膳食纤维对大鼠生长、血清脂质含量、肝脏脂质含量及肝脏组织病理的不同影响,并通过测定粪中酸性固醇的排泄量来观察它们对胆汁酸代谢的影响。结果表明:1)四种膳食纤维均能有效地降低进食高脂膳食大鼠的空腹血清总胆固醇含量,对空腹血甘油三酯水平无影响;2)魔芋精粉能较其余三种膳食纤维更有效地降低肝脏组织脂质含量,包括胆固醇及甘油三酯。肝组织病理学检查亦显示魔芋精粉减轻肝脂变效果最佳;3)四种膳食纤维均能增加粪中胆汁酸尤其是鹅脱氧胆酸的排泄量,推测这可能是它们降低机体脂质的机理之一;4)四种膳食纤维在5％摄入水平对大鼠摄食及生长无不良影响。
In order to evaluate appropriately the role of lipid metabolism by the refined konjac meal (RKM), a new source of dietary fiber, the effects of RKM on the level of serum and liver lipids, hepatic histopathology and on the composition and output of fecal bile acids in comparison with pectin, algin and agar were studied.The RKM contained about 75-80% of glucomannan. All four kinds of dietary fiber 'were given at a level of 5% in the diet to the young male Wistar rats fed on a lipid-rich diet containing 5% lard, 1% cholesterol and 0.25% chplate. The control group was fed on a lipid-rich diet alone withput fiber. The normal group was fed on a basal diet without extra lipid added. Feeding period was 9 weeks.The results obtained were as follows;1)All the dietary fibers tested have the similar effects on serum lipid composition. At the end of 2-week of the experiment, the serum total cholesterol levels of the four experimental groups were only 62% to 75% of that of the control group, and at the end of 7-week they were lowered to the same level of the normal group. The level of the triglyceride in serum did not change in all groups during the experiment.2)Relative liver weights were lower in four experimental groups than in control group. Hepatic hisiopathological examinations showed lipotropic effect in RKM, pectin and algin groups. Both of the above effects appeared most significantly in RKM group. The concentrations of total cholesterol and triglyceride in liver in RKM group were lower than those in control group as well as other three experimental groups.3)No harmful effects on the intake of food and growing of rats were found when feeding these four kinds of dietary fiber at the level of 5%.4)The daily output of fecal bile acids (CDCA + GDCA) was significantly increased in four experimental groups.The increase of fecal output of bile acids, especially CDCA, may be one of the mechanisms of hypocholesterola-emic effect of dietary fibers.It could be concluded that RKM has the same significant hypocholestero-lemic effect as the pectin, algin and agar, but its lipotropic effect is more potent.
出处
《营养学报》
CAS
CSCD
北大核心
1993年第2期130-136,共7页
Acta Nutrimenta Sinica
关键词
魔芋精粉
果胶
琼脂
血清脂质
refined konjac meal (RKM) pectin agar algin serum lipids liver lipids fecal bile acids
