摘要
目的 观察解毒消痰散结方在不同时间内对S1 80 荷瘤小鼠的抑瘤作用。方法 用解毒消痰散结方汤药给予昆明小鼠灌胃 ,1次 日 ,剂量为 17g kg ,给药 6d后 ,皮下种植S1 80 肉瘤建立动物模型 ,分别再给药 7、14、2 1d后处死取瘤体。疗效评价采用瘤体称重法。结果 解毒消痰散结方在接种后给药 7、14d对S1 80 荷瘤小鼠的抑瘤率各为 87.5 7%、73.37% ,分别高于其在接种后给药 2 1d的抑瘤率 (4 2 .2 7% ) (P <0 .0 1)。结论 解毒消痰散结方在种植性肿瘤早期的抑瘤效果较好 。
Objective To study the anti-tumor effect of Jiedu Xiaotansan Recipe for mouse transplanted sarcoma 180. Methods 0.2ml of prepared sarcoma 180 suspension was inoculated subcutaneously to mouse after taken 17g/kg ⅹ d of Jiedu Xiaotansan Recipe oral liquid for 6 days, and then 17g/kg ⅹ d of Jiedu Xiaotansan Recipe oral liquid was given to mice for 7 days, 14 days and 21 days. The anti-tumor effect of Jiedu Xiaotansan Recipe was evaluated by the method of tumor- weighing. Results The inhibiting rate on mouse transplanted sarcoma 180 in 7 days and 14 days were 87.57% and 73.37%, respectively. They were higher than that in 21 days (47.27%, P<0.05). Conclusion The anti-tumor effect of Jiedu Xiaotansan Recipe earlier period may be better than that during the late period.
出处
《河北中医》
2004年第10期793-795,共3页
Hebei Journal of Traditional Chinese Medicine
