摘要
目的:观察白花丹参茎叶水提物对小鼠耐缺氧作用的影响,分析白花丹参茎叶的药用价值。方法:实验于2002-11/2003-05在泰山医学院药学院药物综合实验室完成。80只小鼠随机分为6组,分别灌胃给予生理盐水、普萘洛尔和不同剂量的白花丹参茎叶水提物,观察小鼠缺氧存活时间和耗氧量变化。结果:灌胃给予白花丹参茎叶水提物10,20,30,40g/kg和普萘洛尔20mg/kg,使小鼠0～5min的耗氧量分别降低5.32%,7.73%,19.64%,20.78%和22.81%,5～10min的耗氧量分别降低3.53%,2.29%,9.35%,11.29%和16.58%。灌胃给予氯化钠注射液、普萘洛尔20mg/kg和白花丹参茎叶水提物10,20,30,40g/kg,小鼠缺氧25min的存活率分别为0,80%,0,0,40%和40%。普萘洛尔组、白花丹参茎叶水提物30和40g/kg组,小鼠的缺氧存活时间分别延长48.20%,21.28%和17.08%。结论:白花丹参茎叶水提物能明显增强小鼠的耐缺氧作用。
AIM:To study the effect of aqueous extract from stems and leaves of Salvia mil tiorrhiza bag.f.alba on hypoxia tolerance in mice,and evaluate the medicinal val ue of the stems and leaves. METHODS:The experiment was finished in the Comprehensive Laboratory of Pharmac ology,College of Pharmacology,Taishan Medical University from November 2002 to M ay 2003.Eighty mice were divided randomly into six groups and intragastrically a dministered respectively with saline, propranolol and different dosages of aqueo us extract from stems and leaves of Salvia miltiorrhiza bag.f.alba.The survival time and oxygen consumption were measured in mice. RESULTS:When mice were intragastrically administered with aqueous extract from stems and leaves of Salvia miltiorrhiza bag.f.alba at the dose of 10,20,30,40 g /kg and propranolol at the dose of 20 mg/kg,the oxygen consumption was reduced r espectively by 5.32%,7.73%,19.64%,20.78%and 22.81%for 0 to 5 minutes and 3. 53%,2.29%,9.35%,11.29%and 16.58%for 5 to 10 minutes.The survival rates of m ice with hypoxia for 25 minutes were 0, 80%,0,0,40%and 40%when receiving sali ne,propranolol of 20 mg/kg and aqueous extract from stems and leaves of Salvia m iltiorrhiza bag.f.alba of 10,20,30 and 40 g/kg.The survival time was prolonged by 48.20%,21.28%and 17.08%in mice with hypoxia of propranolol and aqueous extract from stems and Salvia miltiorrhiza bag.f.alba of 30 and 40 g/kg groups. CONCLUSION:Aqueous extract from stems and leaves of Salvia miltiorrhiza bag.f. alba shows obvious effect in enhancing hypoxia tolerance in mice.
出处
《中国临床康复》
CSCD
北大核心
2005年第1期115-117,共3页
Chinese Journal of Clinical Rehabilitation
基金
山东省教育厅科研基金资助项目(J04E07)~~
