摘要
目的:研究失语症的发病与恢复机制,为失语症患者语言恢复提供理论依据,是当前脑血管病研究的热点之一。资料来源:应用计算机检索Medline1980-01/2004-01期间的相关文章,检索词“aphasia,recovery”,“aphasia,hypoperfusion”,“aphasia,metabolic”,并限定语种为English。同时计算机检索万方数据库2002-01/2004-10期间的相关文章,检索词为失语症。限定文章语言种类“”为中文。资料选择:对资料进行初审,选取有关失语症发病及恢复机制的相关文献,然后筛除明显不随机临床试验的研究,对剩余的文献查找全文,进一步判断是否为随机对照临床研究(RCT)。纳入标准为RCT,无论是否为单盲,双盲或非盲法。资料提炼:共收集到34篇关于失语症发病及恢复机制的相关文献,26个试验符合纳入标准。排除的8篇试验中,均为重复的同一研究。资料综合:26试验包括620例患者,分别对失语症发病及恢复机制进行了论述。结论:关于失语症发病及恢复机制,目前尚无统一的结论。语言中枢的低灌注、低代谢可能为失语症的发病机制,脑语言功能的可塑性可能为失语症的恢复机制。
OBJECTIVE:It is one of the hotspot researches on cerebrovascular disease to st udy the onset and recovery mechanism of aphasia for providing theoretical eviden ce in the rehabilitation of aphasia patients. DATA SOURCES:With computer, a MEDLINE search of English language articles pub lished from January 1980 to January 2004 was performed using the searching terms “aphasia, recovery', “aphasia, hypoperfusion', “aphasia, metabolic',“latera lization, language'.Meanwhile,the compute search of Chinese language articles p ublished in Wanfang database between January 2002 to October 2004 was also perfo rmed by using the term of aphasia in Chinese. STUDY SELECTION:After the raw screen on the data,pertinent literature about th e mechanism on onset and recovery of aphasia were selected.Non randomized clini cal trials were excluded,and randomized controlled trials (RCT) were included th rough the screen on full test to determine whether a RCT or not.Either single an d double blinded or unblended RCT were eligible. DATA EXTRACTION:Of the 34 articles on the onset and recovery mechanism of apha sia extracted, only 26 articles met the inclusion criteria. The eight articles e xcluded described the same trial. DATA SYNTHESIS:Twenty six trials were included for a total of 620 patients to discuss the mechanism of onset and recovery for aphasia respectively. CONCLUSION:There is no agreement about the mechanism of onset and recovery of aphasia.Hypoperfusion and hypometabolism to language center may be the pathogene sis of aphasia, and brain plasticity may be the recovery mechanism of aphasia.
出处
《中国临床康复》
CSCD
北大核心
2005年第1期144-145,共2页
Chinese Journal of Clinical Rehabilitation
