摘要
他汀类调脂药是一种胆固醇生物合成酶系中甲羟戊酰辅酶 (HMG CoA)还原酶抑制剂 ,其除调脂作用外有许多非降脂作用。本文综述了此类药物通过改善内皮功能、抑制炎症反应、抑制平滑肌细胞的增生和促进凋亡、减少脂质在血管内皮的沉积、减少泡沫细胞的形成、抑制血小板的活性和聚集等达到抗动脉粥样硬化作用的研究进展。
Statins are HMG CoA reductase inhibitors. In addition to the function of regulating the serum lipid, they also have many other functions. In this article, I focus on the study of statins in anti-atherosclerosis. They can improve the function of endothelium; inhibite the inflammation and the hyperplasia of smooth muscle and induce apoptosis, reduce the aggradation of lipid on the endothelium and reduce the formation of foam cell; and decrease the activity and coagulation of platelet.
出处
《上海第二医科大学学报》
CSCD
2004年第B11期96-98,103,共4页
Acta Universitatis Medicinalis Secondae Shanghai
基金
中央保健委专项科研基金 (沪C0 2 3)资助项目
