摘要
目的研究功能性便秘与结肠黑变病(melanosis coli,MC)之间的关系。方法根据罗马Ⅱ标准选择功能性便秘病人109例,按MC的诊断标准明确其中24例为MC,同时了解便秘程序和服泻药情况,对所有MC患者均行病理学检查。结果 MC患者女性多于男性,发病年龄偏高,本组结肠镜检出率为0.62％,占功能性便秘的22.02％,功能性便秘发生MC均为重度便秘病人,有长期服蒽类泻药史,以全结肠和升结肠部位多见。病理表现为黏膜内含有大量含色素颗粒的单核吞噬细胞沉积,上皮细胞正常。结论功能性便秘是引起MC的主要原因,尤以服蒽类泻剂者为甚,因泻剂可诱导结肠黏膜上支细胞凋亡,且凋亡上皮细胞数量与MC的程度呈正相关,因此,可能会增加患结血肠癌发病的危险性。
Aim To investigate the relationship between functional constipation and melanosis coli(MC). Methods According to Rome Ⅱ. we selected 109 cases who suffered from functional constipation According to the diagnostic standard of MC. we diagnosed 24 cases MC from the above patients. At the same time, we want to understand the degree of constipation and the condition of laxatives consumption. Results In the patients with MC, the female was more than male. According to the result of colonoscopy, the incidence was 0.62% accounting for 22.02% (24/109) of patients with functional constipation. A lot of patients with MC always had a serious constipation and took laxatives for a long time, especially laxatives containing anthracene. The position of MC was more in whole colon and ascending colon than the other position. Pathologically, colonic mucosa contains a lot of monophagocytes with chromatophore granulation, but epithelial cell was normal. Conclusions Functional constipation is main cause to lead to MC. Especially, the patients take laxatives containing anthracene. Because laxative may lead to colonic epithelial apoptosis and there is positive correlation between the degree of epithelial apoptosis and MC. Thus, it may increse the incidence of colorectal carcinomas.
出处
《现代消化及介入诊疗》
2003年第1期30-31,共2页
Modern Interventional Diagnosis and Treatment in Gastroenterology
