摘要
本实验从自由基角度用垂体后叶素(Pit)性心肌缺血模型观察了小鼠心肌营养性血流(NBF),氧自由基(OFR)浓度,丙二醛(MDA)含量和超氧化物歧化酶(SOD)活性的动态变化。结果表明;在Pit引起NBF显著降低的同时OFR浓度显著上升,MDA含量显著增加,SOD活性显著下降。提示Pit性心肌缺血模型有异常显著的自由基反应,这在抗心肌缺血损伤研究中为筛选某些氧自由清除剂提供了方便、廉价、在体的动物模型。
In this study we found that while pituitrin induced a significant decline of nutritional blood flow of myocardium in mice, oxygen free radical concentration andmalondialdehyde content significantly increased, and superoxide dismutase activity signifi-cantly declined in the ischemic myocardium. These results suggest that this pituitrin-inducedmyocardial ischemia in mice may serve as an easy-to-operate, cheap and in vivo model forscreening oxy-radical scavengers in the study of anti-ischemic myocardial injury.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1993年第2期124-128,共5页
Chinese Journal of Pathophysiology
基金
国家中医药管理局重点课题
关键词
心肌缺血
超氧物歧化酶
自由基
Myocardium
Ischemia
Free radicals
Lipid peroxides
Superoxide dismutase
