摘要
为探讨内皮素(endothelin,ET)在机体血压调节中的意义,本文观察ET_A受体拮抗剂BQ_(123)的降压作用。静脉注射BQ_(123)(0.1,1和2mg/kg)后,自发性高血压大鼠(SHR)和正常血压大鼠(WKY)血压呈剂量依赖地降低, 持续40～60分钟。BQ_(123)对SHR的降压作用强于WKY。给Wistar大鼠静脉注射BQ_(123)呈剂量依赖地拮抗外源性ET-1(2×10^(-9)mol/kg)引起的血压升高反应。在培养的SHR主动脉平滑肌细胞上,ET-1(10^(-7)mol/L)促细胞增殖效应(~3H-胸腺嘧啶和~3H-亮氨酸掺入增加)可为BQ_(123)所拮抗。实验结果提示内源性ET可能在一定程度上参与机体正常血压的调节和高血压发病过程,内皮素拮抗剂对于防治高血压病可能具有一定潜在应用价值。
In order to investigate the role of endothelin (ET) in blood pressure re-gulation, the depressor effect of ET_A receptor antagonist -BQ_(123) was observed. After in-travenous administration of BQ_(123) (0.1, 1.0 and 2.0 mg/kg) into spontaneously hyperten-sive rat(SHR) and normotensive WKY rat, their blood pressure decreased in a dose-depen-dent manner, which continued 40-60 min. The blood pressure reducing action of BQ_(123)in SHR was more potent than that in WKY rat. Intravenous injection of BQ_(123) intoWistar rat inhibited pressor reponse induced by exogenous ET-1(2×10^(-9)mol/kg) in adose-dependence manner. ET-1(10^(-7)mol/L) stimulated proliferation of cultured smoothmuscle cells from SHR aorta, i.e., increase in ~3H-thymidine and ~3H-Leucine, however, BQ_(123)effectively antagonized the above action of ET-1. These results suggested that endogenousET to some extent could be involved in the regulation of normotension and also in thedevelopment of hypertension, and that ET antagonists would be useful for clinical preven-tion and therapy of hypertensive diseases.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1993年第6期678-681,共4页
Chinese Journal of Pathophysiology
关键词
高血压
血压
大鼠
Hypertension
Blood pressure
Rats
