摘要
在偏食条件下给大白鼠饮水中加过量氟造成骨软化性氟骨症,引起一系列生化代谢改变。这些变化,在单纯低钙偏食时即已出现,投氟后则进一步加重。本文讨论了骨软化性氟骨症的发病机理,认为食饵低钙是骨软化性氟骨症发生、发展的基本条件;因血钙浓度下降而引发的趋钙激素的变化,使得骨软化愈演愈烈,改善居民钙营养状况,对防治地方性氟中毒具有重要意义。
Experimental osteomalacic skeletal fluo-rosis was produced in rats kept on amonotonous diet of low calcium (Ca) anddirnking water supplemented with excess fluo-ride.The following biochemical and metabolicchanges were found:(1)the serum content ofCa was markedly lowered with no significanfchangein the contents of magnesium and phos-phorus;(2)the serum content of 1,25-(OH)_2D_3 was elevated with an inverse correla-tion to the serum Ca level;(3)the number ofosteoclasts increase,indicating a secondary hy-perparathyroidism in response to the hypocal-cemia;(4)The urine content of hydroxyprolinerose with a direct correlation to the number ofosteoclasts,indicating an increase of bone re-sorption and collagen disintegration;(5)theserum alkaline phosphatase activity was ele-vated correlated inversely with the serum Cacontent,indicating an increased activity of os-teoblastic function.The above mentionedchanges appeared in slight degrees in thegroup fed with monotonous diet only,but wereexacerbated by the administration of excessfluoride.The pathogenesis of osteomalacicskeletal fluoride.The pathogenesis of osteo-malacic skeletal fluorosis is discussed.It isconsidered that low dietary Ca intake is an es-sential factor in the development of osteoma-lacic skeletal fluorosis,that the changes of cal-ciotropic hormones secondary to the hypocal-cemia aggravate the severity of osteomalacia,and that improvement of Ca nutrition state ofthe inhabitants can play an important role inthe control of endemic fluorosis.
出处
《中国地方病学杂志》
CAS
CSCD
1993年第3期132-135,共4页
Chinese Jouranl of Endemiology
关键词
氟骨症
骨软化
低钙血症
Skeletal fluorosis
osteomalacia
hypocalcemia
