摘要
本文同时检测了69例大肠腺癌病人癌组织的 P53基因的突变及 nm23-H_1的表达,并分析其与淋巴结转移的关系。结果示 P53突变率为47.8%,nm23—H_1表达阴性率为43.5%,淋巴结转移密切且 P53的突变和 nm23-H,基因的不表达均与相关,提示 P53基因突变及 nm23-H_1表达降低与大肠腺癌发生有关,同时检测有利于肿瘤预后评价。
p53 mutation and nm23-H_1 expression were examined in 69 cases with colorectal adenocarcinoma and their rela- tions with lymph node metastasis were discussed.The results showed that p53 mutation rate was 47.8％,nm23-H_1 regative expression 43.5％ and both were closly rlative to lymph node metastasis.The results sugguested that p53 mutation and nm23- H_1 expression simultaneously examin may be helpful for evaluating the prognosis。
出处
《现代消化及介入诊疗》
1999年第1期15-16,共2页
Modern Interventional Diagnosis and Treatment in Gastroenterology
