摘要
从手术当日起，给２０例恶性肿瘤患者静脉点滴西米替丁（２０ｍｇ／ｋｇ·ｄ）。结果显示，西米替丁能升高辅助性／诱导性Ｔ细胞（ＣＤ４）和ＣＤ４／抑制性／细胞毒性Ｔ细胞（ＣＤ８），并降低ＣＤ８。用４０例患者术前血标本行体外实验，结果显示西米替丁能升高体外淋巴细胞转化试验（ＬＴＴ）和白细胞介素－２分泌细胞（ＩＬ－２ＳＣ）。表明西米替丁有免疫增强作用，可以用作恶性肿瘤的辅助治疗。
Cimetidine was given intravenously in daily dose of 20mg/kg to 20 patients with malignant tumor from the operative day on. The results show that cimetidine can elevate CD4, CD4/CD8 and decrease CD8. For comparison, blood samples from 40 patients were taken before operation for extracorporal testing. The results show that cimetidine can elevate lpophocyte transformation test and interleukin-2 secretive cell. These indicate that cimetidine can enhance the immune function of the patient and can be used as an adjunctive treatment of neoplasm.
