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γ-氨基丁酸与海人酸致惊厥的关系

RELATIONSHIP BETWEEN GABA AND KAINICACID-INDUCED SEIZURES
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摘要 以大鼠KA惊厥模型探讨了GABA与KA致惊厥的关系。实验证明:①AOAA使惊厥潜伏期延长,惊厥发作程度减弱;②PIC使惊厥发作程度增强;③安定使惊厥潜伏期延长,惊厥发作程度减弱,PIC可去除安定的抗惊厥作用;④惊厥发作时,兴奋性氨基酸Glu、Asp含量减少,抑制性氨基酸GABA含量不变。以上结果表明,KA惊厥发作机制除易感神经元直接兴奋外,可能还涉及脑内GABA能系统功能变化。 The effects of γ-aminobutyric acid (GABA) on ,kainic-acid-(KA)-induced seizures were studied in rats. KA was injected into the peritoneum, and the latent period of seizures was determined by the time between the injection and the first epiletic spire in ECOG. Our results were as follows: 1. The latent period of seizure was lengthened and the incidence was decreased by aminooxiacetic acid (AOAA) or diazepam, and in the effects diazepam was stronger than AOAA. 2. The latent period of seizure was shortened by picrotoxin. 3. Glutamate (Glu) and aspartate (Asp) were reduced in the hippocampus of the rat brain during seizure, but no remarkable change in GABA levels was observed. We suggest that Kainic-acid-induced seizures are probably related to excitatory amino acid, and the GABA system may play an important role.
作者 黄爱华 庄坚
出处 《南通医学院学报》 1989年第4期252-255,340,共4页 ACTA Academiae Medicinae Nantong
关键词 惊厥发作 GABA 海人酸 潜伏期延长 安定 Γ-氨基丁酸 含量 神经元 变化 kainic acid seizure γ-aminobutyric acid electrocorticogram (ECOG) rat
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