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Spectrophotometric Determination of Chlordiazepoxide Using Its Charge-transfer Complex with 2,4-Dinitrophenol 被引量:3

2,4-二硝基苯酚荷移分光光度法测定氯氮卓的含量(英文)
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摘要 A new simple, rapid and sensitive spectrophotometric method for the determination of chlordiazepoxide is described, based on the reaction with 2,4-dinitrophenol in water medium, apparently by a charge-transfer mechanism, to yield 1:1 complex with maximum absorption at 444 nm. Optimum experimental conditions for the determination have been studied. The linear calibration range, apparent molar absorptivity and relative standard deviation are 2.8~96.0 mgmL-1, 1.48103 and 0.32%, respectively. The method is accurate and has been successfully applied to the determination of chlordiazpoxide in tablets. The results are in good agreement with those obtained with the official method. 本文报道了基于氯氮革与2,4-二硝基苯酚在水溶液中的荷移反应测定氯氮革含量的方法。详细研究了荷移反应的条件和影响荷移反应的因素,结果表明,氯氮革与2,4-二硝基苯酚于20℃水溶液中恒温20分钟即可形成l:l的络合物;在其最大吸收波长444nm处表观摩尔吸光系数为ε=1.48×10^3L·mol^-1·cm^-1;并在2.8-96μg·mL^-1范围内符合比尔定律;方法的相对标准偏差为0.32%。将拟定的方法应用于氯氮革片剂样品含量的测定,并与药典法相比较,结果基本一致。
出处 《Journal of Chinese Pharmaceutical Sciences》 CAS 2001年第4期196-199,共4页 中国药学(英文版)
关键词 CHLORDIAZEPOXIDE 2 4-DINITROPHENOL Charge-trandfer reaction SPECTROPHOTOMETRY 含量 药典法 二硝基苯 片剂 分光光度法 荷移反应 比尔定律 苯酚 水溶液 络合物
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参考文献3

  • 1ZhangSigui,ed.TechnicalHandbook ofFineOrganicChemicals[]..1991
  • 2UnitedStatesPharmacopoeiaConventionInc.TheUnitedStatesPharmacopoeia,X X III[]..1995
  • 3WuhanUniversity,ed.AnalyticalChemistry[]..1979

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