摘要
本文对南宁市城区幼儿园和小学3～13岁的122例先天性心血管畸形患儿进行1:2病例对照配对调查研究,探讨其母亲孕早期暴露于某些危险因素(如用药和疾病等)与儿童先天性心血管畸形发生的关系。在比数检验单因素分析基础上,采用条件Logistic模型对资料进行多因素综合分析,筛选出5个与先天性心血管畸形发病有关的危险因素;母亲孕早期使用阿司匹林(OR=8.25)、四环素类药物(OR=7.34)、避孕药(OR=5.23)、以及母亲孕早期罹患风疹(OR=6.88)和感冒(OR=2.98)。
Using 1: 2 matched pair case-control study, the relationship between congenital cardiovascular malformation and maternal exposure to some risk factors during early pregnancy was investigated. 122 children suffering from congenital cardiovascular malformation were taken from kindergartens and elementary schools in urban districts of Nanning. Two controls wereclassmate and neighbour of the diseased child.
According to conditional logistical regression model, multivariate analysis was made on IBM-PC computer. The results showed increased risks associated with maternal intake of aspirin (OR=8.25), tetracycline (OR=7.34), contraceptive medicine (OR=5.23) and maternal rubella (OR=6.88) or common cold (OR=2.98) during early pregnancy. As shown by the statistics, all the other factors analyzed were not significant.
出处
《中国循环杂志》
CSCD
1993年第4期217-220,共4页
Chinese Circulation Journal
关键词
危险因素
孕期
心脏血管疾病
畸形
Congenital cardiovascular malformation
Risk factors
Pregnancy
