摘要
为了寻找新的活性强、毒副作用小的α_1受体阻断剂,设计合成了27个未见文献报道的含芳氧乙胺结构的异喹啉衍生物,结构经元素分析和光谱数据确证。对部分化合物进行了降压活性实验,多数化合物显示不同程度的降压活性。
In search for new α_1-adrenoceptor blockers with high effect and low side-effect, 27 new isoquinoline derivatives having the aroxylethylamine moiety were designed and synthesized. The preliminary pharmacological results showed that the majority of the compounds possessed varying degrees of hypotensive activity. Further pharmacological tests and SAR research are under investigation.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1993年第1期11-17,共7页
Journal of China Pharmaceutical University
关键词
异喹啉衍生物
Α受体阻断药
α_1-Adrenoceptor blockers
Hypotensive activity
Isoquinoline derivatives
Aroxylethylamine moiety
