摘要
以鲁米诺(Luminol)依赖的化学发光法(Chemilumineseence,CL)观察硝苯吡啶对冠心病患者中性粒细胞(Polymorphonuclear Leukocyte,PMN)氧化代谢功能的影响.研究对象包括冠心病未服用硝苯吡啶者24例;服用硝苯吡啶者26例,正常对照者30例。结果表明:冠心病服药组中性粒细胞化学发光强度明显受抑,与冠心病未服药组相比,PMN-CL的本底、峰值及吞噬指数明显减低,与正常对照组相比,PMN-CL的峰值及吞噬指数无差异;而未服药组PMN-CL的本底、峰值及吞噬指数明显高于正常对照组。
Luminol dependent chemilumi-nescence (CL) method was used to observe effect of nifedipine on polymorphonuclear leukocytes (PMN) oxygen metabolism in coronary heart disease (CHD). Studied subjects including 24 cases of coronary heart disease non using nifedipine, 26 cases of coronary heart disease using nifedipine group (10.mg tid on 3~7 days), 30 cases of normal drug-free subjects.
The results showed that: 1. PMN-CL in using nifedipine CHD group was sigrlifficantly lower, its PMN- CL backgroud, peak value and
phargocyte index was signifficantly lower than that in non using nifedipine CHD group. 2. PMN-CL peak value and phargocyte index in using nifedipine CHD group had no signifficantly differences compared with normal group. 3. Parameters of PMN- CL in non using nifedipine CHD group were signifficantly higher than that in normal group.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1993年第2期147-149,共3页
Chinese Pharmacological Bulletin
基金
安徽省科委八五攻关项目
关键词
硝苯吡啶
冠心病
氧
自由基
nifcdipine
coronary heart disease ( CHD )
polymorphoriuclear leukocyte (PMN)
oxygen free radical (OFR)
