摘要
在离体家兔主动脉条.钩藤碱和异钩藤碱明显减少KCl(77.0 mmol·L^(-1))溶液所致45Ca内流量、不影响去甲肾上腺素所引起的45Ca内流和外溢。结果表明.钩藤碱和异钩藤碱对电位依赖性钙通道具有阻滞作用。
The effects of Rhynchophylline (Rhy) and Isorhychophyiline (Isorhy), the alkaloids abstracted from the Chinese traditional herb Uncaria rhynchophyllia (Miq) Jackson, on the 45Ca-influx and efflux were investigated in rabbit aorta. Both Rhy and Isorhy (10 μmol· L-1) inhibited the 45Ca-influx induced by high K+(77. 0 mmol · L-1), but neither significant-
ly influenced the 45Ca-influx and efflux induced by noradrenaline (10 μmol · L-1). The results suggest that these alkaloids block the Voltage-dependent calcium channel.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1993年第6期428-430,共3页
Chinese Pharmacological Bulletin
基金
贵州省科委资助
关键词
钩藤碱
异钩藤碱
钙通道
^45Ca内流
Rhynchophylline
Isorhynchophylline
(45)~Ca-influx voltage-dependent Ca^(2+) channel
vascular smooth muscle
