摘要
采用实验性冠脉狭窄犬模型,冠脉内恒流灌注硝酸甘油和尼可地尔(均为1μg·kg^(-1)·min^(-1)).发现硝酸甘油有两种作用:灌注5min时能扩张冠脉狭窄段(R_L)及狭窄远端小动脉(R_s),增加冠脉血流量(CBF),改善心肌缺血;但灌注10min后.却引起R_L的增加、CBF的减少,使冠状静脉全血粘度(Hb)、血细胞比容(Hct)增加。加重心肌缺血和恶化冠脉循环。尼可地尔能持久和缓和地扩张冠脉.使R_S降低,CBF增加,降低冠状静脉的Hb、Hct.改善缺血区冠脉循环。
To comparet the role of nitrogly-cerin with nicorandil in relieving myocardial ischemia, a critical stenosis of the left anterior descending coronary artery was produced by an ex-
ternal micrometer constrictor in 18 open chest dogs. Intracoronary infusion of nitroglycerin ( 1 μg · kg-1 · min-1) had two effects: decreasing large coronary artery resistance (RL) and small coronary artery resistance (Rs) and increasing coronary blood flow (CBF) in first 5 min so as to relieve myocardial ischemia; then increasing RL, decreasing CBF and increasing whole blood viscosity (ηo) and hematocrit (Hct) in coronary vein after 10 min so as to worsen myocardia ischemia. However, intracoronary infusion of
nicorandil(l μg · kg-1 · min-1) increased CBF and decreased Rs and reduced ηo and Hct in coronary vein. The vasodilatory effect of nico-randil was moderate but long-lasting and it improved blood supply to the ischemic region in coronary circulation.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1993年第6期438-442,共5页
Chinese Pharmacological Bulletin
关键词
冠脉流量
硝酸甘油
尼可地尔
coronary stenosis
myocardial ischemia coronary blood flow
nitroglycerin
nicorandil
