摘要
从地黄中提取分离的多糖成分地黄多糖b(RPS-b),ip或ig给药抑制实体瘤S180的生长,ip给药对Lewis肺癌,B16黑素瘤和H22肝癌亦有效,最适有效剂量都在20mg·kg^(-1)体外实验证明,RPS-b对S180和HL60细胞生长均无明显的直接细胞毒作用.RPS-b在发挥抑瘤作用过程中,能提高S180荷瘤小鼠脾脏T淋巴细胞的增殖能力,并较长时间维持在较高水平;也能部分阻碍瘤株对脾脏天然杀伤细胞(NK)活力的抑制作用.说明RPS-b是一种免疫抑瘤的活性成份,其抑瘤作用是依赖于机体防御系统而间接产生的。
The polysaccharide fraction.Rehmannia glutinosa polysaccharide b(RPS b)was found to inhibit the growth of solid tumors S180,Lewis.B16,and H22 in mice by ip 20 40mg·kg-1 daily for 8 d since the second day of tumor transplantation.It was also effective by oral admin istration in experiments with S180 In vitro experiments.RPS b was ineffective in inhibiting the growth of S180 and HL60 cells.It showed a positive immunomodulatory activity by a prolonged elevation of the proliferation of the splenic T lymphocytes.Itcould also partly block the inhibition of NK.activity caused by tumor cell growth.These results demonstrate that RPS b is an effective antitumor agent through its immune modulatory particularly the cellular immune mechanism.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1993年第2期153-156,共4页
Chinese Journal of Pharmacology and Toxicology
关键词
地黄多糖
S180肉瘤
肺肿瘤
肉瘤
Rehmannia glutinosapolysaccharide S180 sarcoma Lewis lungneoplasms B16 melanoma H22 liver neoplasms HL60 cell lines Tlymphocyte Natural killer cells
