摘要
本实验采用反相高效液相色谱法,比较了10名健康志愿者单剂量口服自制头孢氨苄片剂0.5g 和等剂量的市售头孢氨苄胶囊的生物利用度。结果表明:二种剂型的Tmax、Cmax、AUC 均无显著性差异(P>0.05),片剂与胶囊的相对生物利用度F=95.976%。
The relative bioavailability of Cephalexin in 10 healthy volunteers taking the tablets and the capsules was compared using
reversed phase high-performance liquid chromatography.The results indicated that the T_(max)、C_(max)、AUC of the two formulations
had no statistic difference.The Cephalexin tablets was equivalent in biological effect to the capsules.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1993年第11期483-484,共2页
Chinese Journal of Hospital Pharmacy
关键词
头孢氨苄
高效液相色谱
生物利用度
cephalexin
reversed phase high-performance liquid chromatography
serum concentration
bioavailability
