摘要
30例慢阻肺患者,因隔肌疲劳电阻抗呼吸图显示胸腹反常矛盾呼吸运动,分为A、B两组,分别先后静脉注射参麦注射液和10%葡萄糖注射液,观察其电阻抗呼吸图所示胸壁腹壁运动曲线的变化。使用参麦注射液后有26例在2h内转为同步呼吸运动,有效率显著高于葡萄糖治疗组(P<0.01)。本结果显示参麦液对疲劳膈肌有正性肌力作用。
Diaphragmatic muscle fatigue (DMF) has long been recognized as causing and developingrespiratory failure in patients with chronic obstructive pulmonary disease (COPD). Paradoxicalmotion of thoraco-abdomen is one of asychronous breathing pattern, which is clinical sign of DMF.Thoracoabdominal motion curves were recorded with impedance respirograph (IRG). Indexes, α andM on IRG correlated well to the degrees of asynchronous breathing movement. 30 patients withCOPD, their IRG showed patadoxical motion of thoraco-abdomen were divided randomly inio twogroups of 15 cases. Group A was treated intravenously with Sheng Mai injection at first and withglucose later. Among patients of group B, preceding Sheng Mai injection was glucose. IRG wererecorded before and after treatment. Results showed that the IRG of 26 patients treated with ShengMai injection changed from paradoxical pattern to sychronous one. The difference of the indexes αand M before and after treatment of Sheng Mai injection was statistically significant (P<0.001).Only one patient treated with glucose changed from paradoxical to sychronous pattern. Thedifference of the indexes between treated and non treated with glucose was not statistically signifi-cant (P<0.05). This study suggest that Sheng Mai injection has a positive inotropic effect on fatigueddiaphragmatic muscle.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1993年第2期91-93,共3页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家自然科学基金
关键词
参麦注射液
阻塞性
肺疾病
针剂
Sheng Mai injection
chronic obstructive pulmonary disease
diaphragmatic muscle fatigue
paradoxical motion of thoracoabdomen
sychronous breathing pattern
